{"id":"W2791538403","doi":"10.3389/fgene.2018.00058","title":"Growth of Triple Negative and Progesterone Positive Breast Cancer Causes Oxidative Stress and Down-Regulates Neuroprotective Transcription Factor NPAS4 and NPAS4-Regulated Genes in Hippocampal Tissues of TumorGraft Mice—an Aging Connection","year":2018,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Cancer-related cognitive impairment studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Alberta Cancer Foundation","keywords":"Neurotrophic factors; Transcription factor; Biology; Cancer research; Neuroprotection; Triple-negative breast cancer; Cancer; Internal medicine; Endocrinology; Breast cancer; Neuroscience; Medicine; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008307432,0.0003452749,0.0002174729,0.000403164,0.0001589786,0.0002418934,0.000134611,0.0002462568,0.001685182],"category_scores_gemma":[0.00006412925,0.0001791166,0.000291777,0.0001876659,0.0002921913,0.0002665849,0.0001406536,0.0007570765,0.0003239586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703724,"about_ca_system_score_gemma":0.0002196759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602853,"about_ca_topic_score_gemma":0.002172017,"domain_scores_codex":[0.9998769,0.000006740166,0.0000097831,0.0000350236,0.00003124823,0.00004039767],"domain_scores_gemma":[0.9998842,0.00000677238,0.00004221188,0.00001135684,0.00001134229,0.00004404047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001538781,0.000020548,0.0004134764,0.00001442983,0.000004252777,0.00006155702,0.00002030787,0.00001275768,0.9986112,0.00003446118,0.00002775934,0.0006252704],"study_design_scores_gemma":[0.00002472658,0.0006499644,0.03421087,0.000009240249,0.00003612752,0.0008225128,0.0002035464,0.0004658339,0.9611736,0.0001164577,0.00227928,0.000007869712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965472,0.001187695,0.0007737633,0.0001446819,0.00003208821,0.000009022248,0.0006536926,0.0000456669,0.0006062302],"genre_scores_gemma":[0.9925687,0.001279651,0.0007041456,0.0000686954,0.00001040081,0.00002803863,0.0006171788,0.00002010373,0.004703125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685182,"threshold_uncertainty_score":0.005637467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055954487344739,"score_gpt":0.2568649637146707,"score_spread":0.2463054188412233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}