{"id":"W2791558035","doi":"10.1016/j.celrep.2018.02.090","title":"Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Natural Sciences and Engineering Research Council of Canada; University of British Columbia; ALS Society of Canada; Heart and Stroke Foundation of Canada","keywords":"Autophagy; Cell biology; Biology; Viral replication; Picornavirus; Endosome; Autophagosome; Signal transducing adaptor protein; Coxsackievirus; Virology; Virus; Signal transduction; RNA; Enterovirus; Intracellular; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736984,0.0001169435,0.0001702077,0.00005700933,0.00009913078,0.000009112739,0.00005022091,0.00006786956,0.0002943173],"category_scores_gemma":[0.00007037858,0.00008738495,0.0001134479,0.0001885021,0.00009003529,0.00007756331,0.00004973353,0.00008479541,0.00005484992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000735872,"about_ca_system_score_gemma":0.00005380748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005776562,"about_ca_topic_score_gemma":0.000008731948,"domain_scores_codex":[0.998828,0.00003790616,0.00039475,0.000343114,0.0002468172,0.0001494169],"domain_scores_gemma":[0.9985548,0.00001081738,0.0003026729,0.0008830525,0.0001592265,0.00008938154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001167859,0.000269919,0.04728101,0.00007688118,0.00002229493,0.00002631322,0.000448791,0.000005268986,0.939571,0.00001698782,0.002753705,0.009411032],"study_design_scores_gemma":[0.0001321316,0.0002588856,0.3192385,0.00005384118,0.00003439673,0.00007009672,0.000005814122,0.00008266325,0.6745062,0.0002515128,0.005304787,0.00006112059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925389,0.00005313897,0.001868788,0.0002248696,0.0004222442,0.0005833636,0.000002123269,0.00006641407,0.004240101],"genre_scores_gemma":[0.9961088,0.000005841488,0.0001001784,0.0007650176,0.0002485282,0.00003287436,0.00005336621,0.00001737999,0.002667975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2719575,"threshold_uncertainty_score":0.3563455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396503763615483,"score_gpt":0.3090820768226178,"score_spread":0.295117039186463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}