{"id":"W2791571679","doi":"10.1074/jbc.ra117.001373","title":"Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Cystic Fibrosis Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; Chloride channel; Conductance; Chemistry; Cytoplasm; Transmembrane protein; Biophysics; Ion transporter; Membrane; Crystallography; Biochemistry; Physics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287187,0.000162521,0.0001780172,0.0001563889,0.0001767841,0.0004414715,0.000197261,0.0003427544,0.0008514597],"category_scores_gemma":[0.0002989863,0.000149035,0.0002533717,0.00008568689,0.0004244949,0.0004304034,0.0002631242,0.0003130515,0.00025343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378306,"about_ca_system_score_gemma":0.0001458742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181942,"about_ca_topic_score_gemma":0.0001724033,"domain_scores_codex":[0.9999155,0.00001464055,0.000006892549,0.00002486995,0.00001828624,0.00001986235],"domain_scores_gemma":[0.9996516,0.00007766293,0.0001243855,0.0000268752,0.00003606523,0.00008335467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008399574,0.000007455024,0.0005892474,0.0000160309,0.000001430295,0.00009548311,0.00001859329,0.0001288063,0.9983193,0.0002270917,0.000007950224,0.0005046285],"study_design_scores_gemma":[0.00006429403,0.0005250457,0.05205892,0.00002136266,0.00002885538,0.001380077,0.0002736427,0.01042727,0.9328802,0.0007692034,0.001544682,0.00002651673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957061,0.0001499566,0.003635886,0.00003218256,0.000004797435,0.000004928676,0.00003310707,0.00003073143,0.0004024338],"genre_scores_gemma":[0.9977785,0.0001149107,0.001802986,0.00001703933,0.000004087349,0.000005053724,0.00007283713,0.00000840359,0.0001962638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008514597,"threshold_uncertainty_score":0.002848387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03470289643604707,"score_gpt":0.2980887350054441,"score_spread":0.2633858385693971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}