{"id":"W2791625572","doi":"10.1002/jcph.1073","title":"The Drug–Drug Interaction Profile of Presatovir","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Respiratory viral infections research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"Gilead Sciences","keywords":"CYP3A; Pharmacology; Organic anion-transporting polypeptide; CYP3A4; Pharmacokinetics; Abcg2; P-glycoprotein; Chemistry; Drug interaction; Cobicistat; Medicine; ATP-binding cassette transporter; Transporter; Cytochrome P450; Internal medicine; Multiple drug resistance; Metabolism; Antibiotics; Immunology; Viral load; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007082905,0.0000817801,0.0003740477,0.00009191196,0.0001716574,0.000008750974,0.0003417422,0.00006084837,0.001038861],"category_scores_gemma":[0.001555345,0.00003767158,0.0002212882,0.0002090242,0.001084764,0.000116562,0.0001046599,0.001211777,0.0001341887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003954948,"about_ca_system_score_gemma":0.0003474195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001484896,"about_ca_topic_score_gemma":0.00001094854,"domain_scores_codex":[0.9964109,0.001652124,0.001307102,0.00008264753,0.0003484403,0.0001988079],"domain_scores_gemma":[0.9940367,0.003814339,0.0008485898,0.0002189198,0.0009381994,0.0001432473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01834859,0.001029161,0.0153791,0.00005239415,0.00103985,0.00003438298,0.0004036666,0.00004196622,0.09443486,0.00008627574,0.8184139,0.05073582],"study_design_scores_gemma":[0.006143843,0.00620119,0.05310882,0.00009875366,0.0007620553,0.0005603661,0.0004600977,0.001513577,0.2068149,0.0005492556,0.7236738,0.0001133348],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828181,0.0003428017,0.0000678924,0.00850446,0.003082197,0.000323947,0.000001199357,0.000007659259,0.004851703],"genre_scores_gemma":[0.9920912,0.0006331415,0.00005727862,0.001434895,0.00372756,0.000004394473,1.924371e-7,0.00001182662,0.002039522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.11238,"threshold_uncertainty_score":0.9998744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1483032194275548,"score_gpt":0.5645011660159464,"score_spread":0.4161979465883916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}