{"id":"W2791625572","doi":"10.1002/jcph.1073","title":"The Drug–Drug Interaction Profile of Presatovir","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Respiratory viral infections research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"Gilead Sciences","keywords":"CYP3A; Pharmacology; Organic anion-transporting polypeptide; CYP3A4; Pharmacokinetics; Abcg2; P-glycoprotein; Chemistry; Drug interaction; Cobicistat; Medicine; ATP-binding cassette transporter; Transporter; Cytochrome P450; Internal medicine; Multiple drug resistance; Metabolism; Antibiotics; Immunology; Viral load; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005887168,0.0002376767,0.0004792054,0.0002614006,0.0001527325,0.0004209029,0.0001076631,0.000233389,0.002523572],"category_scores_gemma":[0.001547514,0.00009009093,0.0003494761,0.000298565,0.0001099661,0.0002965197,0.000179935,0.0003626181,0.0002698188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046539,"about_ca_system_score_gemma":0.0002354434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004614266,"about_ca_topic_score_gemma":0.0008518054,"domain_scores_codex":[0.9993387,0.0002452903,0.00007383713,0.0001066045,0.0001936354,0.0000419427],"domain_scores_gemma":[0.9994767,0.0002115363,0.0001460749,0.00002738751,0.0000781963,0.00006009789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0515869,0.002412312,0.2473898,0.001285535,0.003983672,0.001673378,0.0003009581,0.004082159,0.1912887,0.000717197,0.003377758,0.4919017],"study_design_scores_gemma":[0.001865701,0.03655922,0.7985486,0.00009923738,0.003313193,0.00718605,0.0002362668,0.01579919,0.1037471,0.0005982695,0.03194904,0.00009809134],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912032,0.005238253,0.0004193235,0.0001188507,0.00002415948,0.00007296888,0.0005326133,0.00003024336,0.002360444],"genre_scores_gemma":[0.9981657,0.0005914724,0.000274696,0.00007986504,0.000015371,0.0000209102,0.0002899915,0.000003758392,0.0005583105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002523572,"threshold_uncertainty_score":0.008442163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1483032194275548,"score_gpt":0.5645011660159464,"score_spread":0.4161979465883916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}