{"id":"W2791643627","doi":"10.1111/trf.14573","title":"How do we manufacture clinical‐grade interleukin‐15–stimulated natural killer cell products for cancer treatment?","year":2018,"lang":"en","type":"article","venue":"Transfusion","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Instituto de Salud Carlos III; Federación Española de Enfermedades Raras","keywords":"Peripheral blood mononuclear cell; Lymphokine-activated killer cell; NKG2D; Interleukin 2; Cell; Interleukin 15; Immunology; Immunotherapy; Interleukin 21; IL-2 receptor; T cell; Natural killer cell; CD8; Biology; Cytotoxic T cell; Immune system; Cytokine; Interleukin; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002854116,0.0004393904,0.0003331276,0.0002778534,0.000151643,0.001270771,0.0005236653,0.0007891825,0.002230039],"category_scores_gemma":[0.004133988,0.0001843017,0.0003944167,0.0001907119,0.0006848458,0.0008038323,0.0003350354,0.0008052633,0.002485908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004796087,"about_ca_system_score_gemma":0.0009565668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002493469,"about_ca_topic_score_gemma":0.0003000119,"domain_scores_codex":[0.9990261,0.0003122041,0.0001043447,0.00009735224,0.0004019794,0.00005816395],"domain_scores_gemma":[0.9986234,0.0003047242,0.0003047405,0.0001984715,0.0004682375,0.000100504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007742015,0.0006557317,0.01082089,0.00221092,0.0001417474,0.0005065752,0.0003204379,0.004338681,0.6147017,0.007768929,0.009189063,0.3485713],"study_design_scores_gemma":[0.0004228598,0.004551481,0.008083786,0.0008308269,0.0003156294,0.003406302,0.0005609803,0.004153148,0.6251285,0.009476516,0.3429967,0.00007326475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4581941,0.1275381,0.353275,0.02907299,0.003794237,0.0028419,0.001586508,0.001098644,0.02259846],"genre_scores_gemma":[0.5935789,0.04210409,0.3462983,0.006454363,0.0007753633,0.00121838,0.002405231,0.0003287569,0.00683671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002854116,"threshold_uncertainty_score":0.01509422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565745963073918,"score_gpt":0.2955776835934841,"score_spread":0.269920223962745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}