{"id":"W2791643627","doi":"10.1111/trf.14573","title":"How do we manufacture clinical‐grade interleukin‐15–stimulated natural killer cell products for cancer treatment?","year":2018,"lang":"en","type":"article","venue":"Transfusion","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Instituto de Salud Carlos III; Federación Española de Enfermedades Raras","keywords":"Peripheral blood mononuclear cell; Lymphokine-activated killer cell; NKG2D; Interleukin 2; Cell; Interleukin 15; Immunology; Immunotherapy; Interleukin 21; IL-2 receptor; T cell; Natural killer cell; CD8; Biology; Cytotoxic T cell; Immune system; Cytokine; Interleukin; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001082308,0.0002690686,0.0003169729,0.00009762699,0.0002793336,0.00003941368,0.0001320354,0.0003651643,0.001547975],"category_scores_gemma":[0.00002017311,0.0001919872,0.0002264068,0.0001075147,0.0001556791,0.0001720492,0.00001429429,0.0003312472,0.0003091562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008886346,"about_ca_system_score_gemma":0.00004582055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001537554,"about_ca_topic_score_gemma":0.0001468457,"domain_scores_codex":[0.9986742,0.0001402113,0.0003177245,0.0005021055,0.00003349493,0.0003323059],"domain_scores_gemma":[0.9993137,0.00009906932,0.000113702,0.0002974574,0.0001531536,0.00002292672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00227473,0.0004235607,0.0002038697,0.00004045237,0.0002182544,9.988546e-7,0.001360805,0.000002255398,0.8619359,0.00001568771,0.06309199,0.07043157],"study_design_scores_gemma":[0.002453904,0.0008954314,0.0004135603,0.00004007472,0.00008129701,0.000007876436,0.0001319165,0.00002174213,0.4616374,0.00001399895,0.5341616,0.0001412546],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331072,0.009055899,0.0006837017,0.009986379,0.04484675,0.001484945,0.00002020905,0.0002436262,0.0005712951],"genre_scores_gemma":[0.8691374,0.003062038,0.00007784433,0.0002587809,0.0003667776,0.00005937089,0.0001988197,0.00003057029,0.1268084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4710696,"threshold_uncertainty_score":0.9993647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565745963073918,"score_gpt":0.2955776835934841,"score_spread":0.269920223962745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}