{"id":"W2791656744","doi":"10.1186/s10020-018-0005-x","title":"Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction","year":2018,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Glycolysis; Internal medicine; Endocrinology; Heart failure; Oxidative phosphorylation; Carbohydrate metabolism; Ejection fraction; Metabolism; Beta oxidation; Anaerobic glycolysis; Glucose transporter; Chemistry; Medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502155,0.0002392952,0.0001772683,0.0002697876,0.000105647,0.000149602,0.0001101721,0.0001648509,0.0007617736],"category_scores_gemma":[0.0001514024,0.00009030364,0.0001202545,0.0001369184,0.000213088,0.0001424833,0.0002222599,0.0003927568,0.00008533983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410218,"about_ca_system_score_gemma":0.0001167676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002819739,"about_ca_topic_score_gemma":0.0004674873,"domain_scores_codex":[0.999941,0.000008303768,0.000007867551,0.0000141914,0.0000151118,0.00001348499],"domain_scores_gemma":[0.9997309,0.00003661809,0.0001366677,0.00001418604,0.00001860443,0.00006299981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001324549,0.00008439907,0.05227197,0.00006984708,0.0000259348,0.0005757913,0.00004886754,0.00007226226,0.9394259,0.00004494884,0.00007121987,0.005984209],"study_design_scores_gemma":[0.00001673454,0.0009622995,0.879061,0.00001170858,0.00003716747,0.001824273,0.00007038196,0.0003348175,0.117048,0.00009113419,0.0005357518,0.000006593761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979893,0.0006432144,0.0009735022,0.00003766592,0.000009577931,0.000006919131,0.0001104433,0.00001707145,0.0002122853],"genre_scores_gemma":[0.9985123,0.0004203933,0.0006146005,0.00002660964,0.00001018324,0.000009421721,0.0001700705,0.000003637514,0.0002327458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007617736,"threshold_uncertainty_score":0.002548397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403202439995582,"score_gpt":0.2533222800454752,"score_spread":0.2392902556455194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}