{"id":"W2791658715","doi":"10.1002/mrd.22961","title":"TALEN‐mediated gene targeting in porcine spermatogonia","year":2018,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Biology; Transcription activator-like effector nuclease; Nucleofection; Germline; Population; Gene targeting; SOX2; Germ cell; Genetics; Locus (genetics); CRISPR; Gene; Spermatogenesis; Molecular biology; Transfection; Cas9; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003515685,0.0001492781,0.0001163257,0.00008387602,0.0001056811,0.00002006677,0.00006163696,0.00009264634,0.00002312148],"category_scores_gemma":[0.0000911345,0.0001445098,0.00002183523,0.0001448842,0.0000938376,0.000004204255,0.0001046755,0.00006804211,0.00003432977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001912737,"about_ca_system_score_gemma":0.00007129325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009267312,"about_ca_topic_score_gemma":0.000006703714,"domain_scores_codex":[0.9986096,0.00003756692,0.0002794192,0.0007258383,0.0001297768,0.0002177806],"domain_scores_gemma":[0.9994565,0.000001040038,0.00006849426,0.000288239,0.0001160977,0.00006964034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005800354,0.0000491963,0.003885716,0.00001150916,0.00002099744,0.000009953225,0.0001602203,0.00002120035,0.9908462,0.00001381692,0.0007352875,0.004187935],"study_design_scores_gemma":[0.0003306473,0.0001087909,0.01614351,0.000007480818,0.000003253883,0.00008711933,0.00007829408,0.00002056675,0.8081207,0.00001310717,0.1748934,0.0001930822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938118,0.0022162,0.002695853,0.0003693728,0.0002962901,0.0001877328,9.114505e-7,0.00002030932,0.0004015641],"genre_scores_gemma":[0.9923714,0.0002504278,0.005982429,0.0001844715,0.000395552,0.00001666198,0.0001193625,0.0000229462,0.0006567287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1827254,"threshold_uncertainty_score":0.589294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007606011720483532,"score_gpt":0.2271594346179489,"score_spread":0.2195534228974654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}