{"id":"W2791658715","doi":"10.1002/mrd.22961","title":"TALEN‐mediated gene targeting in porcine spermatogonia","year":2018,"lang":"en","type":"article","venue":"Molecular Reproduction and Development","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health","keywords":"Biology; Transcription activator-like effector nuclease; Nucleofection; Germline; Population; Gene targeting; SOX2; Germ cell; Genetics; Locus (genetics); CRISPR; Gene; Spermatogenesis; Molecular biology; Transfection; Cas9; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002893329,0.0002203295,0.0002219975,0.000238371,0.0001667631,0.0003171588,0.0002106417,0.0003669013,0.0007427587],"category_scores_gemma":[0.0001909464,0.0001519023,0.0002340298,0.0001258907,0.0002293954,0.0001793959,0.0002685515,0.0003797089,0.0004339218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132958,"about_ca_system_score_gemma":0.0002090427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003612897,"about_ca_topic_score_gemma":0.0006025249,"domain_scores_codex":[0.9997892,0.00003740245,0.00001997969,0.00005392438,0.0000674332,0.00003207091],"domain_scores_gemma":[0.9999,0.00002484399,0.00002518048,0.00001404233,0.00001644559,0.00001955107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001195551,0.000004410703,0.00007307207,0.00002756702,0.00000201334,0.00002964366,0.00001817612,0.00004966003,0.9984465,0.00006750899,0.00002110503,0.001248464],"study_design_scores_gemma":[0.000008127794,0.0001467976,0.001713247,0.000006889487,0.00001309994,0.000356927,0.00002633204,0.0008704712,0.9916934,0.00004446536,0.005114638,0.000005490495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9092542,0.002185563,0.08257486,0.0001771298,0.0001234565,0.0002057349,0.0006271148,0.0005176765,0.004334271],"genre_scores_gemma":[0.9441385,0.001629317,0.04444826,0.0001492265,0.00001875788,0.0001153381,0.001198315,0.0001438651,0.008158362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007427587,"threshold_uncertainty_score":0.002484798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007606011720483532,"score_gpt":0.2271594346179489,"score_spread":0.2195534228974654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}