{"id":"W2791685657","doi":"10.1016/j.jaci.2018.02.018","title":"Hypersensitivity reactions to therapeutic monoclonal antibodies: Phenotypes and endotypes","year":2018,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":258,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Monoclonal antibody; Phenotype; Medicine; Antibody; Immunology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004443573,0.0001102316,0.0004220997,0.0001331809,0.0001243573,0.00001139417,0.00004696265,0.0001684967,0.00002307708],"category_scores_gemma":[0.0005579457,0.00008446407,0.0001168436,0.00008979781,0.0004629742,0.0001070616,0.00005199073,0.0004864877,0.00003353419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002480708,"about_ca_system_score_gemma":0.0001195337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003415137,"about_ca_topic_score_gemma":0.00006072381,"domain_scores_codex":[0.9988976,0.0001267941,0.0005409592,0.0001616617,0.000100543,0.0001724106],"domain_scores_gemma":[0.9986118,0.0005486044,0.0002296531,0.000150638,0.0002962863,0.0001629946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002347432,0.001535753,0.01162837,0.00002030228,0.01000977,0.0003574697,0.001085237,0.00000298598,0.1343026,0.005681457,0.0003595086,0.8326691],"study_design_scores_gemma":[0.001837198,0.001608677,0.7607434,0.0001034685,0.000270742,0.003818725,0.0009106661,0.00003523954,0.0007932833,0.0006956554,0.2290525,0.0001303979],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860299,0.0006168852,0.0001737527,0.006441164,0.0008426523,0.00008834068,0.000001671397,0.00001462343,0.005791045],"genre_scores_gemma":[0.9927876,0.003392887,0.001706113,0.0009894955,0.0006690327,8.384784e-7,7.292155e-7,0.00001123883,0.0004420706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8325387,"threshold_uncertainty_score":0.3444345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04572586793278312,"score_gpt":0.3581106889560109,"score_spread":0.3123848210232278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}