{"id":"W2791699872","doi":"10.2147/cmar.s155283","title":"<em>MC1R</em> variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project","year":2018,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"School of Medicine, New York University; National Institutes of Health; Universiteit Leiden; Università degli Studi dell'Aquila; Karolinska Institutet; National and Kapodistrian University of Athens; Deutsches Krebsforschungszentrum; Institute of Management Research, College of Business Administration Seoul National University; Pomorski Uniwersytet Medyczny W Szczecinie; Associazione Italiana per la Ricerca sul Cancro; Istituto Oncologico Veneto; Universidad de Murcia; Murdoch Children's Research Institute; Università degli Studi di Genova; INCLIVA Instituto de Investigación Sanitaria; University of Leeds; York University; London School of Hygiene and Tropical Medicine; Children’s Hospital of Wisconsin Research Institute; Leids Universitair Medisch Centrum; National Cancer Institute; Menzies Institute for Medical Research; Yale University; Moffitt Cancer Center; University of Ottawa; University of Minnesota; Cancer Research UK","keywords":"Melanoma; Phototype; Medicine; Receiver operating characteristic; Genotype; Risk factor; Phenotype; Oncology; Internal medicine; Gene; Genetics; Dermatology; Biology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01453576,0.001916927,0.003533661,0.002048215,0.0003768988,0.001253642,0.0009838796,0.0009626453,0.002130067],"category_scores_gemma":[0.01930606,0.000798173,0.01374353,0.001872544,0.0003604689,0.0004465958,0.001482098,0.0005522881,0.0002505343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003201331,"about_ca_system_score_gemma":0.0005465262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00320307,"about_ca_topic_score_gemma":0.003518767,"domain_scores_codex":[0.9882666,0.007455993,0.001123203,0.001989087,0.000898146,0.0002669139],"domain_scores_gemma":[0.9888968,0.005328143,0.002277055,0.002301448,0.0009179174,0.0002784959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.02983369,0.0001026598,0.4230647,0.006570934,0.5152432,0.0005227148,0.0002473051,0.001756492,0.004015303,0.000245618,0.001833182,0.01656424],"study_design_scores_gemma":[0.002016637,0.002328066,0.488607,0.0009442557,0.4980263,0.0007145046,0.0001683529,0.002795201,0.001100627,0.0004337659,0.002791483,0.00007390595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8936225,0.08266784,0.01159733,0.0002767733,0.0001734374,0.0004588087,0.009851186,0.0001746823,0.001177508],"genre_scores_gemma":[0.9887226,0.003557268,0.002513707,0.0001079522,0.0001235725,0.0003294538,0.004229423,0.00005493143,0.0003611586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01453576,"threshold_uncertainty_score":0.07687342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251759070205364,"score_gpt":0.3169187829255286,"score_spread":0.2917428759049922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}