{"id":"W2791699872","doi":"10.2147/cmar.s155283","title":"<em>MC1R</em> variants as melanoma risk factors independent of at-risk phenotypic characteristics: a pooled analysis from the M-SKIP project","year":2018,"lang":"en","type":"article","venue":"Cancer Management and Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"School of Medicine, New York University; National Institutes of Health; Universiteit Leiden; Università degli Studi dell'Aquila; Karolinska Institutet; National and Kapodistrian University of Athens; Deutsches Krebsforschungszentrum; Institute of Management Research, College of Business Administration Seoul National University; Pomorski Uniwersytet Medyczny W Szczecinie; Associazione Italiana per la Ricerca sul Cancro; Istituto Oncologico Veneto; Universidad de Murcia; Murdoch Children's Research Institute; Università degli Studi di Genova; INCLIVA Instituto de Investigación Sanitaria; University of Leeds; York University; London School of Hygiene and Tropical Medicine; Children’s Hospital of Wisconsin Research Institute; Leids Universitair Medisch Centrum; National Cancer Institute; Menzies Institute for Medical Research; Yale University; Moffitt Cancer Center; University of Ottawa; University of Minnesota; Cancer Research UK","keywords":"Melanoma; Phototype; Medicine; Receiver operating characteristic; Genotype; Risk factor; Phenotype; Oncology; Internal medicine; Gene; Genetics; Dermatology; Biology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009635097,0.0001920081,0.0002560043,0.0002074641,0.0004025641,0.00009974035,0.0003915899,0.0001373791,0.0005200865],"category_scores_gemma":[0.00009795617,0.0001336098,0.0001132825,0.0004842863,0.0002066205,0.000009345479,0.0005117833,0.0001733523,0.00002409757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006191261,"about_ca_system_score_gemma":0.00006275109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212989,"about_ca_topic_score_gemma":0.001725692,"domain_scores_codex":[0.9976614,0.0004588263,0.0003081928,0.0005721875,0.0006154756,0.0003839121],"domain_scores_gemma":[0.9988446,0.00006928945,0.0002128055,0.0005597591,0.0002249828,0.00008856221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002643641,0.000397269,0.7805278,0.0001995127,0.01456056,0.00003397531,0.007242708,0.00002876521,0.1178177,0.0006320102,0.02123293,0.05468313],"study_design_scores_gemma":[0.001331036,0.000501299,0.9571769,0.00004045512,0.001231639,5.927024e-7,0.00157617,0.0005768446,0.0220135,0.0002673682,0.01500639,0.0002778362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995153,0.001267876,0.0004482051,0.00005017695,0.0001950416,0.0006211402,0.0003057675,0.000008043994,0.001950766],"genre_scores_gemma":[0.9896491,0.005210501,0.00009640036,0.00004760741,0.0003873782,0.00009605144,0.0003994057,0.00002096405,0.004092618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1766491,"threshold_uncertainty_score":0.5694582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251759070205364,"score_gpt":0.3169187829255286,"score_spread":0.2917428759049922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}