{"id":"W2791743672","doi":"10.1093/jcag/gwy008.120","title":"A119 THE MICROBIAL METABOLITE SENSOR PREGNANE X RECEPTOR (PXR) RESTRAINS FIBROBLASTS FROM PROMOTING INTESTINAL INFLAMMATION AND FIBROSIS IN MICE","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pregnane X receptor; Metabolite; Fibrosis; Pharmacology; Biology; Inflammation; Internal medicine; Microbiology; Chemistry; Endocrinology; Immunology; Medicine; Nuclear receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007989423,0.00008786714,0.0001857501,0.00008365757,0.0001025068,0.0000188082,0.0001738313,0.0001501279,0.000006891138],"category_scores_gemma":[0.0005552017,0.00005958175,0.00006846253,0.00007360094,0.0001043226,0.000009795892,0.00003621506,0.0002016026,0.000001295071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180404,"about_ca_system_score_gemma":0.0002654461,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002639806,"about_ca_topic_score_gemma":0.1927409,"domain_scores_codex":[0.9985741,0.0005156695,0.0004553343,0.0001100897,0.0001124579,0.0002323072],"domain_scores_gemma":[0.9985555,0.00004303383,0.0009142665,0.00009614076,0.0002985153,0.00009253757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002455911,0.00001486964,0.4555823,0.00001626598,0.0001227358,0.000001239249,0.0007353291,0.00003165112,0.5420671,0.00001012645,0.0009930407,0.0001798134],"study_design_scores_gemma":[0.001826592,0.001391773,0.9366705,0.000412374,0.0000781507,0.0001109701,0.0002245651,0.00005509204,0.05406983,0.00005923795,0.005010336,0.00009057006],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918715,0.00005076934,0.00001687719,0.00746807,0.0003411249,0.000146883,0.00005594585,9.67357e-7,0.00004784274],"genre_scores_gemma":[0.9987846,0.00003160826,0.0003734585,0.0002200996,0.0004272222,0.00000135246,0.00001166828,0.000008203266,0.0001417988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4879972,"threshold_uncertainty_score":0.8219895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005302237562644686,"score_gpt":0.2123802545114794,"score_spread":0.2070780169488347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}