{"id":"W2791743672","doi":"10.1093/jcag/gwy008.120","title":"A119 THE MICROBIAL METABOLITE SENSOR PREGNANE X RECEPTOR (PXR) RESTRAINS FIBROBLASTS FROM PROMOTING INTESTINAL INFLAMMATION AND FIBROSIS IN MICE","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pregnane X receptor; Metabolite; Fibrosis; Pharmacology; Biology; Inflammation; Internal medicine; Microbiology; Chemistry; Endocrinology; Immunology; Medicine; Nuclear receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004598388,0.0007112825,0.000563558,0.0008424998,0.0003416784,0.0006890246,0.0004311048,0.0008777676,0.005521213],"category_scores_gemma":[0.0001909275,0.0006227087,0.0008576008,0.0003961743,0.0006428681,0.0005699723,0.0003258559,0.00254887,0.001925701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351671,"about_ca_system_score_gemma":0.0003944066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007096643,"about_ca_topic_score_gemma":0.001378077,"domain_scores_codex":[0.9990985,0.0001335873,0.00009956664,0.0002026775,0.0002628841,0.0002027391],"domain_scores_gemma":[0.9995515,0.00004894377,0.000127292,0.00008757415,0.00003209287,0.0001526473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004572467,0.0001983502,0.000185802,0.00006206542,0.00001164056,0.00008231622,0.00003661029,0.00006207252,0.9968551,0.0002127275,0.0002206969,0.001615228],"study_design_scores_gemma":[0.0002834986,0.002578636,0.005612268,0.00004846299,0.00005837195,0.0007970998,0.0001407828,0.001343819,0.9768643,0.0002587673,0.01199266,0.00002153315],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706233,0.004619088,0.009108583,0.001400953,0.0003586215,0.0001718212,0.005114859,0.0009510239,0.007651854],"genre_scores_gemma":[0.9537527,0.003785989,0.009630254,0.0005209048,0.0001022824,0.0004150351,0.003587682,0.0002018457,0.02800328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005521213,"threshold_uncertainty_score":0.01847029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005302237562644686,"score_gpt":0.2123802545114794,"score_spread":0.2070780169488347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}