{"id":"W2791746799","doi":"10.1113/ep086822","title":"ATP increases [Ca<sup>2+</sup>]<sub>i</sub>and activates a Ca<sup>2+</sup>‐dependent Cl<sup>−</sup>current in rat ventricular fibroblasts","year":2018,"lang":"en","type":"article","venue":"Experimental Physiology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Niflumic acid; Purinergic receptor; PPADS; DIDS; P2Y receptor; Reversal potential; Biophysics; Channel blocker; Patch clamp; Intracellular; Chemistry; Uridine triphosphate; Electrophysiology; Membrane potential; Phospholipase C; Agonist; Cell biology; Internal medicine; Biology; Extracellular; Biochemistry; Calcium; Receptor; Nucleotide; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804026,0.000276542,0.0002395665,0.0001262921,0.00008270977,0.0002517404,0.0002063418,0.0001878058,0.001047772],"category_scores_gemma":[0.0001210252,0.00009139223,0.0002680411,0.0001228127,0.0002262024,0.0003077287,0.00009333469,0.0003534553,0.0002964245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247772,"about_ca_system_score_gemma":0.0001113787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003549085,"about_ca_topic_score_gemma":0.0004268983,"domain_scores_codex":[0.999908,0.00001308622,0.0000176786,0.00001538292,0.00002838724,0.00001759279],"domain_scores_gemma":[0.9998579,0.00004452066,0.00003523715,0.00002060356,0.00002057489,0.00002110928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007987535,0.00001041179,0.0002435405,0.00005328656,0.000003195819,0.0001434798,0.00001703937,0.00001756827,0.9985669,0.00003395978,0.00001240162,0.0008183012],"study_design_scores_gemma":[0.0000185126,0.0007546982,0.02675477,0.00001677453,0.00003531998,0.0008804646,0.0001343829,0.0003740781,0.9694529,0.0001384232,0.001431461,0.000008192306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903171,0.004886209,0.002804036,0.0002002558,0.00003628626,0.00002217092,0.0003284,0.00004535385,0.001360058],"genre_scores_gemma":[0.9933588,0.00256908,0.002121754,0.00009427901,0.00005248899,0.00002874552,0.0002729816,0.00001225075,0.001489643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047772,"threshold_uncertainty_score":0.003505111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008549834014931052,"score_gpt":0.2530712491269106,"score_spread":0.2445214151119795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}