{"id":"W2791751812","doi":"10.1016/j.mcn.2018.03.002","title":"Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons","year":2018,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Rijksuniversiteit Groningen; Canadian Institutes of Health Research; Anneliese Pohl Stiftung; Uniklinikum Giessen und Marburg; European Commission","keywords":"Afterhyperpolarization; Locus coeruleus; SK channel; Apamin; Neuroscience; Biology; Patch clamp; Potassium channel; Electrophysiology; Ion channel; Cell biology; Endocrinology; Nucleus; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0003774995,0.0003587844,0.0003552366,0.0003142582,0.0005668491,0.0001329716,0.001072451,0.0001171239,0.00002526967],"category_scores_gemma":[0.001034043,0.0002772729,0.0001298975,0.002653658,0.00327988,0.0003482386,0.0007055523,0.0006440839,0.00001644556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003246178,"about_ca_system_score_gemma":0.0001573214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000373504,"about_ca_topic_score_gemma":0.000003732646,"domain_scores_codex":[0.9954115,0.0008169426,0.0004511261,0.001367483,0.0009670213,0.0009859294],"domain_scores_gemma":[0.9984296,0.0001330979,0.0002504943,0.0008067528,0.00009498121,0.0002850869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003808583,0.0001701264,0.002437071,0.00001779839,6.98953e-7,0.0006923924,0.00009585212,0.0001173963,0.995724,0.0005844231,0.00002735012,0.0000948481],"study_design_scores_gemma":[0.0004855295,0.0003609621,0.004722724,0.00002681322,0.000009392954,0.0001419757,0.00001850827,0.002442098,0.9907989,0.0004585361,0.0002762817,0.0002582707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958689,0.00005712663,0.0004332929,0.0009884477,0.001478956,0.0006247181,0.00002026491,0.00005417506,0.0004741441],"genre_scores_gemma":[0.9960904,0.00003361186,0.000007767405,0.003539245,0.00004434453,0.00002764742,1.791187e-7,0.00004135604,0.0002154699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004925049,"threshold_uncertainty_score":0.9999679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03605144894903062,"score_gpt":0.2933561132833563,"score_spread":0.2573046643343256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}