{"id":"W2791770260","doi":"10.1016/j.bpj.2017.11.412","title":"Feedforward and Feedback Amplification in the Pink1-Parkin Pathway Generate a Binary Switch for Mitochondrial Quality Control in Parkinson Disease","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Parkin; Mitophagy; PINK1; Mitochondrion; Cell biology; Ubiquitin ligase; Ubiquitin; Biology; Chemistry; Parkinson's disease; Autophagy; Biochemistry; Medicine; Disease; Internal medicine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005109999,0.0003115239,0.0003592866,0.0002544042,0.0004244523,0.001143945,0.0004571366,0.0005431248,0.003292853],"category_scores_gemma":[0.001117545,0.0003174831,0.0002618261,0.0001304762,0.0006310139,0.001199535,0.001027225,0.0008960117,0.0004954141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007351121,"about_ca_system_score_gemma":0.0003540912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002418825,"about_ca_topic_score_gemma":0.0003517549,"domain_scores_codex":[0.9997274,0.00004678545,0.00002145417,0.00005674748,0.00009120328,0.00005635529],"domain_scores_gemma":[0.9995791,0.000137144,0.00006221668,0.0000511457,0.00006259813,0.0001078742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007781456,0.0001306138,0.0006535496,0.00007936812,0.00001462037,0.0001080185,0.00007402757,0.001870058,0.9783064,0.01004125,0.0003124876,0.007631583],"study_design_scores_gemma":[0.0002861985,0.0005067529,0.01078145,0.00003588483,0.00006294669,0.0005366939,0.0002255896,0.09378697,0.8687282,0.02177966,0.003187365,0.00008219251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820978,0.0003677743,0.01315862,0.0007338633,0.0001436091,0.00002398563,0.0001381089,0.0002956387,0.003040582],"genre_scores_gemma":[0.9976082,0.00006561906,0.001463879,0.00004670721,0.00000892428,0.000009962602,0.0000314648,0.00001958675,0.0007456961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003292853,"threshold_uncertainty_score":0.01101571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923862423238299,"score_gpt":0.3151455761526323,"score_spread":0.2859069519202493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}