{"id":"W2791802626","doi":"10.3233/jad-170909","title":"A Network of Genetic Effects on Non-Demented Cognitive Aging: Alzheimer’s Genetic Risk ( <i>CLU + CR1 + PICALM</i> ) Intensifies Cognitive Aging Genetic Risk ( <i>COMT + BDNF</i> ) Selectively for <i>APOE</i> <i>ɛ</i> 4 Carriers","year":2018,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; National Institute on Aging; University of Alberta","keywords":"Cognitive aging; Apolipoprotein E; Cognition; Genome-wide association study; Psychology; Medicine; Genetics; Psychiatry; Biology; Disease; Gene; Internal medicine; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006294951,0.0003595126,0.0004467374,0.0009671697,0.0003781417,0.0004440185,0.0003282136,0.0002721079,0.002347908],"category_scores_gemma":[0.001860918,0.0001915566,0.0005756439,0.0005711635,0.0004117729,0.0002781572,0.0006712193,0.0002582771,0.0001454002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331527,"about_ca_system_score_gemma":0.0005572142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006349292,"about_ca_topic_score_gemma":0.007402751,"domain_scores_codex":[0.9995029,0.0001558909,0.00002187077,0.0002198207,0.00005228698,0.00004719061],"domain_scores_gemma":[0.998852,0.0003705866,0.0003219205,0.0001550047,0.0001225961,0.0001777546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001121645,0.0000980903,0.9734795,0.00002350788,0.0005535726,0.0001562374,0.0001347136,0.001503797,0.01308976,0.0004545284,0.0001916477,0.009193085],"study_design_scores_gemma":[0.00002408659,0.0002023158,0.9942492,0.000006823816,0.0002667484,0.0002450102,0.00007468571,0.003307978,0.0006279708,0.0008078406,0.000178588,0.000008749029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978084,0.000119016,0.001299858,0.00005088846,0.00000193304,0.00001822941,0.0002529483,0.00001942305,0.0004293464],"genre_scores_gemma":[0.9979243,0.00005510062,0.001392156,0.00002802485,0.000003038351,0.00001956751,0.0003424525,0.0000055323,0.0002297333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006349292,"threshold_uncertainty_score":0.01262468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02228017716919026,"score_gpt":0.3029423778649932,"score_spread":0.2806622006958029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}