{"id":"W2791809191","doi":"10.1007/s10456-018-9606-9","title":"Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling","year":2018,"lang":"en","type":"article","venue":"Angiogenesis","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"Oncosuisse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Allosteric regulation; Angiogenesis; Cell biology; Kinase insert domain receptor; Vascular endothelial growth factor; Receptor tyrosine kinase; Chemistry; Ligand (biochemistry); Signal transduction; Receptor; Tyrosine kinase; Cancer research; Vascular endothelial growth factor A; Biology; Biochemistry; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004176738,0.0002566634,0.0004230679,0.0001469648,0.0002224041,0.0002981386,0.0007794118,0.0003647018,0.00279992],"category_scores_gemma":[0.000597374,0.0001523385,0.0002690546,0.0001176292,0.0003334056,0.0002423003,0.0002043465,0.0006124784,0.0004889758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003679056,"about_ca_system_score_gemma":0.0004331087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007139249,"about_ca_topic_score_gemma":0.0007100842,"domain_scores_codex":[0.9998096,0.00004188146,0.00001429556,0.00003717916,0.00005337267,0.00004368585],"domain_scores_gemma":[0.9998063,0.00007055982,0.00003194344,0.00002909857,0.0000272166,0.00003485992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003601628,0.0001777587,0.0003919467,0.00005452438,0.00001747302,0.0001433484,0.00002554013,0.0007872343,0.9925213,0.001261704,0.0001442157,0.004114763],"study_design_scores_gemma":[0.00007780236,0.00032491,0.000828263,0.000005890743,0.00002119025,0.0002482705,0.00001524112,0.004732718,0.9914076,0.0001966172,0.002128536,0.00001309384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793295,0.0008875743,0.01634208,0.0002978026,0.00009892398,0.0001078868,0.000282628,0.0001580306,0.002495711],"genre_scores_gemma":[0.9932811,0.0002494863,0.004688624,0.0000996482,0.00001305212,0.00003513695,0.0002813589,0.00002206355,0.001329552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00279992,"threshold_uncertainty_score":0.009366691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009558338609553,"score_gpt":0.2248935635535876,"score_spread":0.214797980167492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}