{"id":"W2791819857","doi":"10.1007/s00259-018-3933-3","title":"Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"European Journal of Nuclear Medicine and Molecular Imaging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Concordia University; Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Institute of Aging; Pfizer; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association","keywords":"Biomarker; Neurodegeneration; Positron emission tomography; Standardized uptake value; Medicine; Oncology; Alzheimer's disease; Fluorodeoxyglucose; Disease; Internal medicine; Voxel; Pittsburgh compound B; Pathology; Neuroscience; Nuclear medicine; Psychology; Biology; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001776981,0.0001242966,0.0003626347,0.0003105348,0.00003560353,0.000011608,0.0001012119,0.00001272144,0.0001040963],"category_scores_gemma":[0.000958105,0.00009004881,0.0000685751,0.0001546265,0.0005454863,0.00008613342,0.0001333355,0.0003156964,0.000003164471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004522592,"about_ca_system_score_gemma":0.00004916546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006496534,"about_ca_topic_score_gemma":5.013604e-7,"domain_scores_codex":[0.9983304,0.000378975,0.0005226821,0.000173331,0.0004006005,0.0001939723],"domain_scores_gemma":[0.9989806,0.00008887651,0.0001883729,0.0001273505,0.0002547943,0.0003600192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004895025,0.0008464433,0.2487021,0.0002684539,0.0007707671,0.01446641,0.003556235,0.00000118319,0.4008379,0.000633375,0.02651601,0.2985061],"study_design_scores_gemma":[0.008629478,0.002330319,0.9009829,0.001180226,0.0007407786,0.0004241435,0.0008576455,0.0003217771,0.001774197,0.000163572,0.0824395,0.0001555196],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434768,0.01717042,0.0002232559,0.0357108,0.00007310393,0.0001624656,0.000001460828,0.000007210745,0.003174497],"genre_scores_gemma":[0.9852954,0.0007501785,0.0006888334,0.01293865,0.0002817913,2.253876e-7,0.000001829223,0.00003091678,0.00001222538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6522807,"threshold_uncertainty_score":0.3672084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896456689370178,"score_gpt":0.3509814132434574,"score_spread":0.3220168463497556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}