{"id":"W2791823830","doi":"10.1093/neuros/nyy018","title":"Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma (INTRAGO): An Open-Label, Dose-Escalation Phase I/II Trial","year":2018,"lang":"en","type":"article","venue":"Neurosurgery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"Clinical Trial Center, China Medical University Hospital","keywords":"Medicine; Clinical endpoint; Radiation therapy; Tolerability; Adverse effect; Surgery; Confidence interval; External beam radiotherapy; Progression-free survival; Internal medicine; Brachytherapy; Chemotherapy; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001173851,0.001262266,0.001398337,0.0004092069,0.000305206,0.0008995518,0.0007881994,0.0009955567,0.00303226],"category_scores_gemma":[0.0006999673,0.0003582814,0.0009778735,0.0003707724,0.0007405769,0.0005978984,0.0004344965,0.002999652,0.000580887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006029974,"about_ca_system_score_gemma":0.000819893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005947123,"about_ca_topic_score_gemma":0.002395861,"domain_scores_codex":[0.99975,0.0001270468,0.00001194862,0.00004073334,0.0000244174,0.00004593157],"domain_scores_gemma":[0.999584,0.00006147877,0.0001246056,0.00003557728,0.00002187638,0.0001723557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8213257,0.04347271,0.003364358,0.002372565,0.001475095,0.0001927375,0.0003663055,0.002246447,0.02049865,0.0003820493,0.003770652,0.1005327],"study_design_scores_gemma":[0.7242728,0.2639473,0.005374146,0.0001297488,0.0005538115,0.0002021575,0.00008146696,0.0009546846,0.001664903,0.0003240061,0.002467526,0.00002745756],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919938,0.003575389,0.0004342174,0.0003815185,0.0001407439,0.001518767,0.0004884836,0.00009638087,0.001370751],"genre_scores_gemma":[0.9871669,0.003916122,0.001302505,0.001051341,0.0001791183,0.003212426,0.001035078,0.00003567546,0.00210077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303226,"threshold_uncertainty_score":0.01014394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04792831208621618,"score_gpt":0.3567326991077667,"score_spread":0.3088043870215506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}