{"id":"W2791854743","doi":"10.1038/s41593-018-0275-1","title":"Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders","year":2018,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":711,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institute on Alcohol Abuse and Alcoholism; H. Lundbeck A/S; Center for Individualized Medicine, Mayo Clinic; Gillings School of Public Health; Agency for Healthcare Research and Quality; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Avera Institute for Human Genetics; Yale University; U.S. Department of Veterans Affairs; Stiftelsen för Strategisk Forskning; National Institute on Drug Abuse; University of Pennsylvania; Vetenskapsrådet; Virginia Commonwealth University; Georgia Clinical and Translational Science Alliance; Wellcome Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; ZonMw; Karolinska Institutet; Lundbeckfonden; National Institute of Mental Health; Pfizer","keywords":"Genome-wide association study; Alcohol dependence; Neuroscience; Psychology; Psychiatry; Neuroimaging; Alcohol; Genetics; Single-nucleotide polymorphism; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01004760446724133,"score_gpt":0.2909674999132904,"score_spread":0.2809198954460491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["nonrandomized_trial","observational","bench_or_experimental"],"consensus_intersection":["observational","bench_or_experimental"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.0026855878538185702,"metaepi_narrow":0.000045777065690089265,"metaepi_broad":0.00010681315327687495,"bibliometrics":0.00007629510948348211,"sts":0.00015259021896696422,"scholarly_communication":0.00012207217517357137,"open_science":0.0008697642481116961,"research_integrity":0.0016327153429465172,"randomized_trial":0.000015259021896696422,"nonrandomized_trial":0,"observational":0.869062333104448,"systematic_review":0.000030518043793392844,"meta_analysis":0,"case_report":0.0007019150072480354,"qualitative":0.000015259021896696422,"simulation_or_modeling":0.000045777065690089265,"bench_or_experimental":0.1292133974212253,"theoretical_or_conceptual":0.000686655985351339,"not_applicable":0.006149385824368658,"design_other":0.003219653620202945},"gemma":{"metaresearch":0.0011444266422522317,"metaepi_narrow":0.00006103608758678569,"metaepi_broad":0.0004882887006942855,"bibliometrics":0.00012207217517357137,"sts":0.0004119935912108034,"scholarly_communication":0,"open_science":0.00166323338673991,"research_integrity":0.0006713969634546426,"randomized_trial":0.000015259021896696422,"nonrandomized_trial":0.0006561379415579462,"observational":0.7336690318150606,"systematic_review":0,"meta_analysis":0.000015259021896696422,"case_report":0.0006103608758678569,"qualitative":0.000015259021896696422,"simulation_or_modeling":0.0011139085984588387,"bench_or_experimental":0.04281681544213016,"theoretical_or_conceptual":0.0053711757076371405,"not_applicable":0.007766842145418479}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}