{"id":"W2791855321","doi":"10.1002/pbc.26931","title":"Clinical and genetic associations for carboplatin‐related ototoxicity in children treated for retinoblastoma: A retrospective noncomparative single‐institute experience","year":2018,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Clinical Evaluative Sciences; Public Health Ontario; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Carboplatin; Ototoxicity; Medicine; Thiopurine methyltransferase; Chemotherapy; Hearing loss; Oncology; Internal medicine; Retinoblastoma; Genetics; Audiology; Cisplatin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002972081,0.0003012704,0.0005247207,0.0001868788,0.0003651518,0.00007355953,0.0002691175,0.0002643712,0.00001815483],"category_scores_gemma":[0.00235833,0.000314928,0.0001219719,0.0009553692,0.000518138,0.0001661955,0.0001106204,0.0003071598,0.000006505743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736154,"about_ca_system_score_gemma":0.0002882591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003169735,"about_ca_topic_score_gemma":0.0006553927,"domain_scores_codex":[0.9970169,0.0001689543,0.0008268884,0.001054608,0.0002983285,0.0006343016],"domain_scores_gemma":[0.9982589,0.0005060604,0.0004456992,0.0003142107,0.0002818346,0.0001932995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000915624,0.0003243206,0.990878,0.00001449697,0.00003009154,0.000002718003,0.001499626,0.00004836084,0.006528776,0.00005795307,0.0001455779,0.0003784478],"study_design_scores_gemma":[0.003903233,0.001052935,0.9671759,0.00002182997,0.0002466003,0.0000133278,0.00002849586,0.002707645,0.02403582,0.0002708336,0.0001148266,0.0004285677],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957514,0.0002375667,0.0004230537,0.00007847101,0.0005051637,0.002302022,0.0003192867,0.0001052168,0.000277859],"genre_scores_gemma":[0.9950543,0.0002499738,0.00251819,0.0001792721,0.001140006,0.0006529874,0.000007806478,0.00004647269,0.0001509987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02370219,"threshold_uncertainty_score":0.9999303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04888321276298827,"score_gpt":0.3514019291961785,"score_spread":0.3025187164331902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}