{"id":"W2791875139","doi":"10.1016/j.omtn.2018.03.007","title":"CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer’s Disease","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; National Institutes of Health; Marcus och Amalia Wallenbergs minnesfond; Hjärnfonden; National Center for Research Resources; National Institute of General Medical Sciences; Kosciuszko Foundation","keywords":"CRISPR; Amyloid precursor protein; Biology; Mutant; Allele; Cas9; Point mutation; Gene; Transgene; Genetics; Molecular biology; Alzheimer's disease; Disease; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931131,0.000276245,0.0002074453,0.00004388852,0.0001346111,0.00003069527,0.000465639,0.0001507102,0.00003575191],"category_scores_gemma":[0.00005238909,0.0002158868,0.0003003242,0.0001695763,0.000238757,0.00000576444,0.000102432,0.00009877642,0.000008526314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001020949,"about_ca_system_score_gemma":0.00006910752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001799506,"about_ca_topic_score_gemma":0.000002697182,"domain_scores_codex":[0.9985779,0.00008969656,0.0002710505,0.000450875,0.0002514298,0.0003590258],"domain_scores_gemma":[0.9988201,0.00001352619,0.0001033836,0.0007801724,0.0001444603,0.0001384059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008775669,0.0002754788,0.004171574,0.00003414895,0.0005705793,0.000002635684,0.0003642859,0.0002341056,0.985289,0.0001511932,0.0008320909,0.007197383],"study_design_scores_gemma":[0.002451024,0.001114256,0.02831359,0.00001968882,0.0002185807,0.00001813105,0.0001343178,0.002626438,0.9288619,0.0005380959,0.03509508,0.0006088757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8944419,0.004666657,0.09917407,0.0002247326,0.0001798486,0.0008780003,0.0000691081,0.00003743107,0.0003282312],"genre_scores_gemma":[0.9970347,0.0002124435,0.001222423,0.0007935963,0.0002000272,0.0001386378,0.0001981876,0.00008297573,0.0001169663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1025928,"threshold_uncertainty_score":0.8803609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408906767177368,"score_gpt":0.2980079156000912,"score_spread":0.2839188479283175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}