{"id":"W2791888954","doi":"10.1056/nejmoa1710922","title":"Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":405,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Center for AIDS Research, University of Washington; National Institute for Health and Care Research; Wellcome Trust","keywords":"Cryptococcal meningitis; Antifungal; Cryptococcosis; Cryptococcus neoformans; Meningitis; Medicine; Microbiology; Biology; Virology; Immunology; Human immunodeficiency virus (HIV); Pediatrics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003074854,0.00008435134,0.0004655442,0.0002579884,0.00004635606,0.000002161425,0.00003026316,0.0000340708,0.0001176396],"category_scores_gemma":[0.0003278699,0.0000507858,0.00007420321,0.0001819826,0.0001343804,0.00003480748,0.000004901675,0.00005294183,9.166712e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006380738,"about_ca_system_score_gemma":0.00009435864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007485049,"about_ca_topic_score_gemma":0.00005862287,"domain_scores_codex":[0.9991978,0.00002444208,0.0004247806,0.00006617876,0.0001616603,0.0001251861],"domain_scores_gemma":[0.9990395,0.0002581166,0.0001632851,0.00007385678,0.0003623349,0.0001029206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008343774,0.004975393,0.2894634,0.0002828641,0.001650477,0.0003646617,0.03546009,0.00002942321,0.08601215,0.009382469,0.1126945,0.4513409],"study_design_scores_gemma":[0.2881995,0.0958229,0.1673144,0.001503297,0.0009293782,0.001440436,0.001358722,0.0003446926,0.01011566,0.004105462,0.428661,0.0002045473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712737,0.002698922,0.002530613,0.01024646,0.0009519823,0.0004588676,0.000007248294,0.000009252279,0.011823],"genre_scores_gemma":[0.9956686,0.0003398007,0.001281347,0.00002825194,0.002018891,0.00000460354,0.000002303654,0.000007019164,0.0006491978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4511363,"threshold_uncertainty_score":0.2070985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05798650243405418,"score_gpt":0.3376288505914131,"score_spread":0.2796423481573589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}