{"id":"W2791894605","doi":"10.3233/jad-179911","title":"Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches","year":2018,"lang":"en","type":"review","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Disease; Neuroscience; Dementia; Medicine; Clinical trial; Bioinformatics; Pathogenesis; Alzheimer's disease; Psychology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001130873,0.001121772,0.004622957,0.001338539,0.0001241592,0.00009875106,0.0007153641,0.0004660416,0.0005496104],"category_scores_gemma":[0.0007361918,0.0008037242,0.003256518,0.0009651924,0.0004094554,0.0003444672,0.0003360759,0.001500794,0.001050674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001353863,"about_ca_system_score_gemma":0.004752467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003627458,"about_ca_topic_score_gemma":0.000006128077,"domain_scores_codex":[0.9916555,0.001696569,0.003179376,0.001274487,0.001169711,0.001024329],"domain_scores_gemma":[0.9903361,0.0005585094,0.001511431,0.001408183,0.0004506866,0.005735111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007159241,0.006894976,0.02009098,0.00121189,0.1063319,0.006667458,0.0000410721,0.00000452118,7.668758e-8,0.00004979138,0.01530147,0.8362466],"study_design_scores_gemma":[0.004888404,0.001300714,0.1404026,0.009340967,0.1933673,0.000120318,0.00002295269,0.0000259499,0.000001671343,0.0002304982,0.6492963,0.001002327],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00171422,0.9928205,0.00001021835,0.0005899692,0.001564006,0.002425262,0.0007310885,0.00004514751,0.00009960846],"genre_scores_gemma":[0.006294614,0.9874404,0.0003330692,0.0005330479,0.004124294,0.0002098777,0.0008296031,0.0002175901,0.00001752237],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8352443,"threshold_uncertainty_score":0.9997271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2276933178735465,"score_gpt":0.4190902176433258,"score_spread":0.1913968997697794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}