{"id":"W2791896731","doi":"10.1093/jcag/gwy008.199","title":"A198 PHARMACODYNAMIC EFFECTS OF THE ORAL, NON-STEROIDAL FARNESOID X RECEPTOR AGONIST GS-9674 IN HEALTHY VOLUNTEERS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"","keywords":"FGF19; Medicine; Internal medicine; Placebo; Pharmacodynamics; Pharmacokinetics; Endocrinology; Cmax; Agonist; Farnesoid X receptor; Pharmacology; Gastroenterology; Receptor; Chemistry; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008036392,0.0001200802,0.0002815324,0.0001700717,0.00009341379,0.00001149351,0.0006190935,0.0001673942,0.00002047907],"category_scores_gemma":[0.0004777133,0.00008781112,0.0002011568,0.0001622855,0.0002097619,0.000009224912,0.0001011414,0.0003515288,0.000002990098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000648337,"about_ca_system_score_gemma":0.0005585806,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004347189,"about_ca_topic_score_gemma":0.3410939,"domain_scores_codex":[0.998027,0.0006166468,0.0004963163,0.0001337834,0.0003001521,0.0004260782],"domain_scores_gemma":[0.9984009,0.00003937967,0.0008188682,0.0002276775,0.0003594536,0.0001537255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007170858,0.00004932914,0.6828632,0.00004080161,0.0001381918,0.000001296098,0.00009920724,0.00005451589,0.3065458,0.000002343353,0.009413314,0.00007490101],"study_design_scores_gemma":[0.004631297,0.004972452,0.9049023,0.0001323424,0.00005323932,0.00004021686,0.00005606655,0.0001412687,0.07794449,0.00001863921,0.006997744,0.0001098819],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933903,0.00002929652,0.00002318412,0.005246544,0.001009837,0.0002097102,0.00004255122,7.42235e-7,0.00004784283],"genre_scores_gemma":[0.9985926,0.00003025219,0.00006180167,0.000902202,0.0001815377,0.000002931413,0.000004595424,0.00001604779,0.0002079935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3367468,"threshold_uncertainty_score":0.6709294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004824275323661608,"score_gpt":0.2475604934601296,"score_spread":0.242736218136468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}