{"id":"W2791896731","doi":"10.1093/jcag/gwy008.199","title":"A198 PHARMACODYNAMIC EFFECTS OF THE ORAL, NON-STEROIDAL FARNESOID X RECEPTOR AGONIST GS-9674 IN HEALTHY VOLUNTEERS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"","keywords":"FGF19; Medicine; Internal medicine; Placebo; Pharmacodynamics; Pharmacokinetics; Endocrinology; Cmax; Agonist; Farnesoid X receptor; Pharmacology; Gastroenterology; Receptor; Chemistry; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005663249,0.0006505052,0.0007305618,0.0002636578,0.0003766004,0.0002883889,0.0002072089,0.0005895476,0.00289145],"category_scores_gemma":[0.0005058715,0.0003637248,0.0005185953,0.000171853,0.000436708,0.0003642605,0.0002066401,0.000628258,0.0005066461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002285736,"about_ca_system_score_gemma":0.0003398165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071799,"about_ca_topic_score_gemma":0.001448008,"domain_scores_codex":[0.9997221,0.0001055121,0.00002064046,0.00006506927,0.00003968329,0.00004698856],"domain_scores_gemma":[0.9997659,0.00003996091,0.00005622186,0.00003334417,0.00002924166,0.00007530682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5580618,0.03084892,0.01812696,0.0005923906,0.0007338731,0.0004408596,0.0003088068,0.0008601532,0.3043213,0.0001089419,0.001282364,0.08431358],"study_design_scores_gemma":[0.02678147,0.7843202,0.143029,0.00002217654,0.0009208702,0.0005492038,0.0001716394,0.001219589,0.03935549,0.0001402642,0.003430733,0.00005939076],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981559,0.0006012681,0.0002153772,0.00002720084,0.0000150222,0.0001870377,0.0003325879,0.00002756368,0.0004381345],"genre_scores_gemma":[0.9970086,0.0003485632,0.0004428846,0.00008783997,0.00003355509,0.0001757978,0.0003777588,0.000005749376,0.001519273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00289145,"threshold_uncertainty_score":0.00967288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004824275323661608,"score_gpt":0.2475604934601296,"score_spread":0.242736218136468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}