{"id":"W2791913107","doi":"10.1002/jlb.4a0816-354r","title":"Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation","year":2018,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Physicians' Services Incorporated Foundation","keywords":"Hsp90; Heat shock protein; Biology; Caspase 8; Apoptosis; Septic shock; Molecular biology; Caspase 3; Hsp90 inhibitor; Cell biology; Sepsis; Immunology; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009891107,0.0002301198,0.0002622301,0.00009964561,0.00007503761,0.0001610698,0.0001012908,0.0001647081,0.0009065545],"category_scores_gemma":[0.0001094918,0.00007913209,0.0002390435,0.00007997521,0.0001126825,0.0001512443,0.0001479432,0.0004576713,0.0002593738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001073842,"about_ca_system_score_gemma":0.0001179412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001622411,"about_ca_topic_score_gemma":0.0002744301,"domain_scores_codex":[0.9999013,0.00001711264,0.00001360871,0.00001549108,0.00002412217,0.00002845802],"domain_scores_gemma":[0.9999524,0.00000376456,0.00001786317,0.000006416203,0.000007465054,0.00001197135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003002651,0.00004235549,0.0002203314,0.00007209124,0.00001023781,0.00004485533,0.00001285274,0.00004624893,0.9954706,0.00004808852,0.00008968103,0.003642417],"study_design_scores_gemma":[0.00006962943,0.001530126,0.01655737,0.00001593254,0.00003669164,0.0008201356,0.00004649263,0.0007637577,0.976804,0.00008741536,0.003261039,0.000007379559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923104,0.00458543,0.002099207,0.0001069779,0.0000390813,0.00002167176,0.0001962016,0.00007852927,0.0005626454],"genre_scores_gemma":[0.9969525,0.001170906,0.0006943755,0.00005491808,0.00001097796,0.00002456095,0.0003374622,0.000006019064,0.0007482435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009065545,"threshold_uncertainty_score":0.003032744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01722752892997928,"score_gpt":0.2855551006372521,"score_spread":0.2683275717072728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}