{"id":"W2791921126","doi":"10.1073/pnas.1720962115","title":"Double-stranded DNA break polarity skews repair pathway choice during intrachromosomal and interchromosomal recombination","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Government of Canada","keywords":"Recombination; Polarity (international relations); Genetics; Biology; DNA; DNA repair; Cell biology; Gene; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004652471,0.00008652535,0.00009254042,0.00006099388,0.0001524133,0.00001773017,0.0002868033,0.000100159,0.000005481686],"category_scores_gemma":[0.0001768399,0.00006744684,0.00005550486,0.0001928359,0.0004922303,0.00002815878,0.0001526395,0.00009031963,2.914732e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001153049,"about_ca_system_score_gemma":0.00002003909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007922136,"about_ca_topic_score_gemma":0.000001143924,"domain_scores_codex":[0.9990913,0.000004613964,0.0002124648,0.0002466684,0.0003178396,0.0001271058],"domain_scores_gemma":[0.9996214,0.00001409443,0.0001374399,0.00001159769,0.0001823825,0.00003307722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000310441,0.00002413455,0.008304931,0.00004925965,0.00001349976,3.028785e-9,0.00007977561,0.000004940689,0.9902726,0.0009616825,0.00004511763,0.0002129949],"study_design_scores_gemma":[0.0003400294,0.0001035966,0.1728737,0.00003634632,0.000005644202,0.00001865403,0.00003378172,0.0002211749,0.8253433,0.0007884287,0.0001678129,0.00006764548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980235,0.00009255185,0.000005196966,0.0003457544,0.00002992841,0.0001116487,0.00000767959,0.00001016181,0.001373613],"genre_scores_gemma":[0.9988527,0.00002008615,0.000801259,0.00003346407,0.0002009055,0.000004700106,4.916475e-7,0.000004374342,0.00008207018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1649294,"threshold_uncertainty_score":0.2750402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202033922991497,"score_gpt":0.3137459236260072,"score_spread":0.2935425313268575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}