{"id":"W2791942395","doi":"10.1016/j.bbrc.2018.01.138","title":"Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Government of Ontario","keywords":"Pleckstrin homology domain; Chinese hamster ovary cell; Binding site; C-terminus; Plasma protein binding; Biochemistry; Chemistry; Binding domain; Cell biology; Biophysics; Biology; Membrane; Amino acid; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690651,0.0002896385,0.0002896222,0.0001873835,0.0002645842,0.0003401077,0.0004119274,0.0004218891,0.002516301],"category_scores_gemma":[0.0003630691,0.0002977058,0.0002854289,0.00008360176,0.0003896001,0.0005424116,0.0004781464,0.0005356781,0.001268676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308521,"about_ca_system_score_gemma":0.0002623111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004981143,"about_ca_topic_score_gemma":0.0007286067,"domain_scores_codex":[0.9998585,0.00002277119,0.00001469546,0.00002858521,0.0000362996,0.00003913989],"domain_scores_gemma":[0.9995578,0.00009876317,0.0001299458,0.00006457594,0.00004490303,0.0001039704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000160328,0.00001827547,0.0004091386,0.00002428932,0.000002956309,0.0001506078,0.00001457199,0.00004734599,0.9982719,0.0001541375,0.0000410026,0.0007054047],"study_design_scores_gemma":[0.00003886368,0.0000744242,0.02311214,0.000006791329,0.000009056121,0.001201315,0.00007844825,0.00205577,0.9714101,0.0002298302,0.001775592,0.000007634408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931383,0.0002899629,0.005379152,0.00009743527,0.00001853982,0.00001455121,0.0002285136,0.00008729627,0.0007461749],"genre_scores_gemma":[0.9941519,0.00009982425,0.002915788,0.00004140424,0.000008042141,0.00002020801,0.0008148759,0.00003709719,0.001910858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002516301,"threshold_uncertainty_score":0.008417845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05341744268148515,"score_gpt":0.3277134172951398,"score_spread":0.2742959746136547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}