{"id":"W2791951941","doi":"10.1128/aac.00082-18","title":"Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Capsid; Hepatitis B virus; Molecular biology; Chemistry; Virology; In vitro; RNA; Cytotoxicity; Hepatitis B; Biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393157,0.0001474289,0.0004088083,0.00006517054,0.00006617079,0.000008668038,0.00007487536,0.0001083146,0.0004380437],"category_scores_gemma":[0.00003607481,0.0001287865,0.00006647436,0.0001116208,0.0003400383,0.00009920014,0.00003779555,0.00007443831,0.0000165161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002147128,"about_ca_system_score_gemma":0.00006569841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001823254,"about_ca_topic_score_gemma":0.0005931691,"domain_scores_codex":[0.9989249,0.00003885699,0.0004564903,0.0002644311,0.0001388692,0.0001764429],"domain_scores_gemma":[0.999234,0.00002231008,0.0002097096,0.0002324879,0.0002265968,0.00007488098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004097693,0.0006064033,0.3835638,0.0001743393,0.0001532559,0.000002384021,0.001617885,9.312114e-8,0.5771056,0.00002345875,0.01644554,0.01989751],"study_design_scores_gemma":[0.001458696,0.001006695,0.3853218,0.0001608826,0.00004091371,0.000005335807,0.00000991995,0.0000534087,0.6084818,0.00001575564,0.003341034,0.0001038035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981645,0.00004287298,0.00004982819,0.0003847284,0.000163807,0.0004460505,0.00009300494,0.00002317784,0.0006320094],"genre_scores_gemma":[0.9932147,0.00307636,0.001785543,0.001260922,0.0003314459,0.000006091217,0.00004476854,0.00002795084,0.0002521935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03137621,"threshold_uncertainty_score":0.5251761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748124737499438,"score_gpt":0.3136690221813911,"score_spread":0.2861877748063967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}