{"id":"W2791951941","doi":"10.1128/aac.00082-18","title":"Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Capsid; Hepatitis B virus; Molecular biology; Chemistry; Virology; In vitro; RNA; Cytotoxicity; Hepatitis B; Biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004896155,0.0008069979,0.0006518234,0.0004148514,0.0003364028,0.0006029512,0.0006016013,0.0005642704,0.003448715],"category_scores_gemma":[0.0003250423,0.0002660471,0.0004705308,0.0002623141,0.0002992204,0.0003612248,0.0001336491,0.001548408,0.0008338916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003872018,"about_ca_system_score_gemma":0.0008944477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00131797,"about_ca_topic_score_gemma":0.002198472,"domain_scores_codex":[0.9998673,0.00003870797,0.000007628305,0.00001592185,0.00003036106,0.00003995749],"domain_scores_gemma":[0.999805,0.00003008923,0.0000260949,0.00002275543,0.00003865985,0.00007738177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02170233,0.0282768,0.001344658,0.0005120607,0.0002686177,0.0004848139,0.0002447217,0.003586375,0.8653833,0.000788409,0.002953286,0.07445475],"study_design_scores_gemma":[0.01184773,0.4136454,0.0133864,0.0001018493,0.0005550916,0.001255664,0.0002216927,0.004996315,0.5272925,0.0007531433,0.02588749,0.00005649038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976646,0.005572134,0.003518078,0.000430897,0.0001798106,0.001410391,0.001632001,0.000416331,0.01019441],"genre_scores_gemma":[0.9837885,0.004309885,0.001580757,0.0002416064,0.00006216775,0.0006745287,0.0028862,0.00005144391,0.006404924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003448715,"threshold_uncertainty_score":0.01153713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748124737499438,"score_gpt":0.3136690221813911,"score_spread":0.2861877748063967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}