{"id":"W2791957709","doi":"10.3389/fnins.2018.00047","title":"Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders","year":2018,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Québec Consortium for Drug Discovery; Fondation Brain Canada","keywords":"Drug discovery; Induced pluripotent stem cell; Open science; Neuroscience; Computer science; Translational research; Stem cell; Computational biology; Data science; Medicine; Bioinformatics; Biology; Embryonic stem cell; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":["open_science"],"domain":null,"study_design":"not_applicable","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":["metaresearch","open_science"],"domain":"reproducibility","study_design":"design_other","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["open_science"],"consensus_categories":[],"category_scores_codex":[0.006623906,0.00100725,0.001173603,0.001881527,0.00137402,0.004854814,0.001737149,0.003210617,0.01065475],"category_scores_gemma":[0.004309987,0.0004691965,0.001295363,0.001048828,0.005485145,0.006569174,0.005049219,0.006945143,0.004088565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00270792,"about_ca_system_score_gemma":0.00457606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125437,"about_ca_topic_score_gemma":0.00234954,"domain_scores_codex":[0.996962,0.0009206643,0.0001276762,0.0003103119,0.001456084,0.0002232587],"domain_scores_gemma":[0.9969404,0.001097096,0.0002225273,0.0003558619,0.0005832565,0.0008008704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003268982,0.0003061623,0.0005651144,0.001133626,0.0001363797,0.0005482996,0.000694424,0.001449045,0.02144827,0.4229604,0.1398473,0.4105841],"study_design_scores_gemma":[0.000192873,0.0004297114,0.0002826701,0.0003961682,0.00007660357,0.0005255262,0.0002243415,0.001104132,0.007394813,0.2066027,0.782721,0.00004954254],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0154468,0.2253918,0.2584078,0.3518635,0.02597057,0.000800198,0.001806523,0.003092638,0.1172202],"genre_scores_gemma":[0.1952019,0.3380086,0.2338922,0.1244426,0.02343236,0.001423971,0.002357443,0.0007943516,0.08044661],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9982628,"threshold_uncertainty_score":0.0356437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04700102043857651,"score_gpt":0.3336071977617853,"score_spread":0.2866061773232088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}