{"id":"W2791984994","doi":"10.3233/jad-171013","title":"A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer’s Disease and Mild Cognitive Impairment","year":2018,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Eisai; Servier; Lundbeckfonden; National Institute of Neurological Disorders and Stroke; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Cerebrospinal fluid; Cognitive impairment; Disease; Medicine; Cognition; Phosphorylation; Alzheimer's disease; Biomarker; Neuroscience; Internal medicine; Psychology; Oncology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001895491,0.0004429353,0.0003201511,0.0006867229,0.0006720981,0.0006594813,0.000390244,0.0005577937,0.0004558876],"category_scores_gemma":[0.004164611,0.0004430007,0.000475681,0.000634718,0.0003017785,0.0005706234,0.0004813606,0.00075328,0.0002412756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005130065,"about_ca_system_score_gemma":0.0005833419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008730433,"about_ca_topic_score_gemma":0.007679093,"domain_scores_codex":[0.9991875,0.0002750346,0.00005283314,0.0002088125,0.0001683669,0.0001072547],"domain_scores_gemma":[0.9974602,0.0003163996,0.0008318293,0.0002988614,0.0005531471,0.00053941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005358674,0.0001466881,0.9969491,0.000005415427,0.0001524344,0.00007673453,0.0001786525,0.00002012257,0.000628856,0.00001042945,0.00005667581,0.001239004],"study_design_scores_gemma":[0.00001175719,0.0003091045,0.9990162,0.000003544715,0.00004981087,0.0001811983,0.00008406006,0.0001064396,0.00009640484,0.00001783895,0.0001204063,0.000003262108],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994528,0.0002295331,0.00007020066,0.00001736156,0.000006501388,0.000005438468,0.00008829379,0.000002776871,0.0001271758],"genre_scores_gemma":[0.9993278,0.00008117536,0.0001145376,0.00001779933,0.000007492534,0.000008288861,0.0002399,0.000001229955,0.0002017602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008730433,"threshold_uncertainty_score":0.01735926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143435154739644,"score_gpt":0.2988233534474323,"score_spread":0.2673890019000358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}