{"id":"W2792012965","doi":"10.3389/fimmu.2018.00236","title":"Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Alfred Österlunds Stiftelse; Lund University Medical Faculty Foundation; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; Stiftelsen för Strategisk Forskning; European Commission; Torsten Söderbergs Stiftelse; Kungliga Fysiografiska Sällskapet i Lund; Knut och Alice Wallenbergs Stiftelse; Lunds Universitet; European Molecular Biology Organization","keywords":"Streptococcus pyogenes; Extracellular; Microbiology; Cytokine; Chemistry; Histone; Bacteria; Biology; Biochemistry; Immunology; DNA; Staphylococcus aureus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036733,0.0003797862,0.0004032252,0.0002780355,0.0001213105,0.0003355562,0.0001400169,0.0002418615,0.001463543],"category_scores_gemma":[0.0001960766,0.0001088843,0.0002809573,0.000148466,0.0002036067,0.0001114986,0.0003166627,0.0004177186,0.0003495469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053023,"about_ca_system_score_gemma":0.0001805819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719775,"about_ca_topic_score_gemma":0.0004176262,"domain_scores_codex":[0.9997862,0.00005316491,0.00001558052,0.00003039977,0.00007353725,0.00004112719],"domain_scores_gemma":[0.9998699,0.00002383648,0.00003495776,0.00001362368,0.00001808972,0.00003959292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559872,0.00002887389,0.0007283756,0.00007468242,0.00002131497,0.00007135358,0.00002045545,0.00002991101,0.9950191,0.00007031404,0.00007619926,0.003703403],"study_design_scores_gemma":[0.00002818358,0.0006982844,0.01652166,0.00002017979,0.00003583039,0.0005466961,0.00004265162,0.0006816252,0.9756129,0.0000624335,0.005743438,0.000006113312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733237,0.0161777,0.006061001,0.0002154737,0.0001391944,0.00008626295,0.0001871513,0.0001153249,0.003694129],"genre_scores_gemma":[0.9919717,0.00181981,0.003086819,0.00009037725,0.00005965567,0.00002100572,0.0003255771,0.00001464053,0.002610463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001463543,"threshold_uncertainty_score":0.004895985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172953160290123,"score_gpt":0.2470994950076883,"score_spread":0.229804178978676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}