{"id":"W2792067873","doi":"10.1073/pnas.1720553115","title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Centre hospitalier de l'Université Laval; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Government of Canada","keywords":"Platelet; Degranulation; Immune system; Immunology; Serotonin; Receptor; Antibody; Shock (circulatory); Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007014432,0.00008415904,0.0001309689,0.0001339853,0.0001946818,0.00001524369,0.0002939607,0.00007912158,0.0001447752],"category_scores_gemma":[0.0003692076,0.00006177386,0.00003792548,0.0003634483,0.0006508615,0.0002279312,0.0001181827,0.00007613971,0.00001475644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002847472,"about_ca_system_score_gemma":0.00002598658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009687317,"about_ca_topic_score_gemma":2.972001e-7,"domain_scores_codex":[0.999089,0.00001951253,0.0003387773,0.0002166198,0.0002010862,0.0001350202],"domain_scores_gemma":[0.9993162,0.00007894439,0.0002927906,0.0000108899,0.0002826888,0.00001852121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006636696,0.00002127525,0.03307947,0.00002944257,0.00001647094,5.610352e-9,0.0002376605,0.000002270474,0.9636685,0.002405986,0.0003295664,0.0001430222],"study_design_scores_gemma":[0.0002427956,0.00008488807,0.7722074,0.00009500972,0.00001269113,0.00001385215,0.0001042456,0.0001637181,0.2231368,0.00359922,0.0002648608,0.00007441884],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977135,0.0001894258,0.000001229506,0.001185291,0.00003159967,0.0003844511,0.00005305102,0.00001525717,0.0004261903],"genre_scores_gemma":[0.9994455,0.000004952431,0.0002249412,0.0002119188,0.00003472236,0.00002889524,0.000002534008,0.000003245295,0.00004329331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7405316,"threshold_uncertainty_score":0.2519065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04104450508494279,"score_gpt":0.3009877260940989,"score_spread":0.2599432210091561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}