{"id":"W2792095404","doi":"10.1111/jth.13999","title":"Basic weapons to degrade C3a and C5a","year":2018,"lang":"en","type":"letter","venue":"Journal of Thrombosis and Haemostasis","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Anaphylatoxin; Complement system; Complement membrane attack complex; Alternative complement pathway; Context (archaeology); C3-convertase; Innate immune system; Complement receptor; Classical complement pathway; Antibody opsonization; Atypical hemolytic uremic syndrome; Cell biology; Biology; Immunology; Acquired immune system; Immune system; Complement component 2; Inflammation; Properdin; Phagocytosis; Opsonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005922229,0.0004005777,0.0003263723,0.0001752021,0.0007258986,0.0009678709,0.0003430348,0.005455488,0.005156731],"category_scores_gemma":[0.002869229,0.000116717,0.0003177741,0.00009048923,0.001166709,0.0009876611,0.0006034556,0.007406666,0.002159712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007622594,"about_ca_system_score_gemma":0.0004539802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000286499,"about_ca_topic_score_gemma":0.0003900556,"domain_scores_codex":[0.999631,0.0001183995,0.00002542155,0.00003280901,0.0001178181,0.00007443937],"domain_scores_gemma":[0.9994055,0.0003128778,0.00004995604,0.00004764276,0.00008261801,0.0001015072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000559626,0.0002148917,0.001802482,0.0003647407,0.00005446032,0.02584763,0.0003379294,0.0002226776,0.01412432,0.0657893,0.7842646,0.1064173],"study_design_scores_gemma":[0.0001958489,0.0002236352,0.0007941867,0.0001725767,0.00002353299,0.02739023,0.0001762048,0.0004249175,0.0060865,0.03160697,0.9328853,0.00002019812],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01570323,0.04516558,0.003433653,0.8540851,0.03313059,0.00005670447,0.00009459089,0.0001277668,0.04820273],"genre_scores_gemma":[0.3282609,0.02720227,0.004283256,0.476941,0.09460954,0.0001578465,0.0001607091,0.00005460182,0.06832988],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005455488,"threshold_uncertainty_score":0.01725096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06952331372770122,"score_gpt":0.3177166902862876,"score_spread":0.2481933765585864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}