{"id":"W2792095404","doi":"10.1111/jth.13999","title":"Basic weapons to degrade C3a and C5a","year":2018,"lang":"en","type":"letter","venue":"Journal of Thrombosis and Haemostasis","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Anaphylatoxin; Complement system; Complement membrane attack complex; Alternative complement pathway; Context (archaeology); C3-convertase; Innate immune system; Complement receptor; Classical complement pathway; Antibody opsonization; Atypical hemolytic uremic syndrome; Cell biology; Biology; Immunology; Acquired immune system; Immune system; Complement component 2; Inflammation; Properdin; Phagocytosis; Opsonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003770344,0.0003719103,0.000991718,0.0004013815,0.0002480818,0.00009156024,0.0003636185,0.0005189251,0.00143801],"category_scores_gemma":[0.0001182773,0.0002950246,0.0002462631,0.0001191309,0.0002523024,0.0001103291,0.0002343648,0.0008200267,0.0001203265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006891017,"about_ca_system_score_gemma":0.00009282102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004961155,"about_ca_topic_score_gemma":0.00001639191,"domain_scores_codex":[0.9980529,0.0003049108,0.0007550863,0.0003389486,0.0001233434,0.0004248039],"domain_scores_gemma":[0.9984563,0.0002657156,0.0006405992,0.000339295,0.0002142939,0.00008382372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005531288,0.00004428353,0.002085957,0.000127869,0.001006696,0.00003115966,0.0002700878,6.61863e-8,0.002303732,0.00001168914,0.991699,0.002364186],"study_design_scores_gemma":[0.0009431777,0.0006024812,0.01359636,0.0006087743,0.0007830487,0.0003503968,0.0002033021,1.224332e-7,0.002131615,0.0001313701,0.9803157,0.0003336653],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3777553,0.0121744,0.00004929051,0.6056138,0.002606214,0.0005254595,0.0008174689,0.00003099438,0.0004270535],"genre_scores_gemma":[0.3303517,0.005297879,0.001583616,0.6519292,0.00628246,0.0000524028,0.0003229021,0.0002483678,0.003931444],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04740356,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06952331372770122,"score_gpt":0.3177166902862876,"score_spread":0.2481933765585864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}