{"id":"W2792098908","doi":"10.1016/j.vaccine.2018.01.078","title":"Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice","year":2018,"lang":"en","type":"article","venue":"Vaccine","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Jiangsu Science and Technology Department; National Natural Science Foundation of China; Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"Biology; CD8; DNA vaccination; T cell; Cytotoxic T cell; Virology; Immune system; Immunology; Molecular biology; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003744076,0.000822863,0.0004700611,0.0005031149,0.0001805601,0.0004488679,0.0002574199,0.0005613709,0.001701349],"category_scores_gemma":[0.0002139906,0.0003068542,0.0003510118,0.0001615241,0.0003555342,0.0005119435,0.0002864288,0.002069412,0.0005235401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998269,"about_ca_system_score_gemma":0.0002618179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518052,"about_ca_topic_score_gemma":0.0003598148,"domain_scores_codex":[0.9996672,0.00005844217,0.00003212546,0.00007495933,0.00004812335,0.0001190614],"domain_scores_gemma":[0.9997547,0.00005705194,0.00006479744,0.00003363032,0.0000194195,0.00007035936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005579526,0.0002848259,0.0001104503,0.00003613315,0.00000913752,0.00005825777,0.00002217593,0.0001342023,0.9976075,0.0001897891,0.0000734136,0.0009160987],"study_design_scores_gemma":[0.0003032861,0.002213135,0.001413808,0.00001228719,0.00005335042,0.0004511165,0.00003833053,0.002083062,0.9915786,0.0001399812,0.001704757,0.000008325289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953955,0.0003510889,0.002481074,0.0001420688,0.00007487443,0.00006540692,0.0002165898,0.0001321583,0.001141324],"genre_scores_gemma":[0.9959763,0.0002758141,0.001214304,0.00009935313,0.00005010394,0.00006045891,0.0002848931,0.00003930967,0.001999565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001701349,"threshold_uncertainty_score":0.005691588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03457557622239779,"score_gpt":0.3250273465249885,"score_spread":0.2904517703025907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}