{"id":"W2792108611","doi":"10.1038/mp.2018.5","title":"Human cerebral organoids reveal deficits in neurogenesis and neuronal migration in MeCP2-deficient neural progenitors","year":2018,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Neurogenesis; Organoid; Neural stem cell; Neuroscience; Progenitor cell; MECP2; Human brain; Corticogenesis; Progenitor; Neuronal migration; Biology; Rett syndrome; Neural development; Cell biology; Stem cell; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871707,0.0003647488,0.0003380237,0.0004129083,0.0002646947,0.0004731471,0.0003070751,0.0003674907,0.002377028],"category_scores_gemma":[0.0002210165,0.0003156219,0.0002825104,0.000301428,0.0004288367,0.0002172151,0.0004788794,0.0009533737,0.0006608044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248902,"about_ca_system_score_gemma":0.0002659931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002953559,"about_ca_topic_score_gemma":0.003043636,"domain_scores_codex":[0.9998171,0.00002198762,0.00002125698,0.00004513577,0.00005441262,0.00004019676],"domain_scores_gemma":[0.9998486,0.00004402008,0.0000258777,0.00003253365,0.00001334361,0.00003558466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403959,0.00001317926,0.0003612468,0.00002129919,0.00001333522,0.0003807255,0.00007647073,0.00009890954,0.9977633,0.0002060412,0.0000689376,0.0008561817],"study_design_scores_gemma":[0.00001724447,0.00006157388,0.006710606,0.000008041381,0.00003995775,0.001469552,0.0001797685,0.0005811316,0.9882908,0.0001279829,0.002506047,0.000007251734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898002,0.001356228,0.004654113,0.0001165978,0.00003793428,0.00002072736,0.001300448,0.000110785,0.002602996],"genre_scores_gemma":[0.9911817,0.0007091438,0.002364351,0.00004020525,0.000003837456,0.00003947637,0.001262484,0.0000704082,0.004328323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953559,"threshold_uncertainty_score":0.007951975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005735544598284651,"score_gpt":0.2288201685875679,"score_spread":0.2230846239892832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}