{"id":"W2792119560","doi":"10.1371/journal.pone.0193128","title":"Most yeast SH3 domains bind peptide targets with high intrinsic specificity","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of Toronto; National Institutes of Health; New Mexico State University","keywords":"Biology; Conserved sequence; Genetics; Computational biology; Sequence alignment; Multiple sequence alignment; Protein domain; Yeast; Function (biology); Saccharomyces cerevisiae; Domain (mathematical analysis); Protein family; SH3 domain; Plasma protein binding; Peptide sequence; Gene; Biochemistry; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568423,0.0003764085,0.0003744701,0.0003347669,0.0003014334,0.0003962883,0.000259883,0.0003788858,0.001869284],"category_scores_gemma":[0.0004131743,0.000207626,0.0004415902,0.000324973,0.0002652988,0.0003762229,0.0002856287,0.0004949742,0.0008836965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002763272,"about_ca_system_score_gemma":0.0001676439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008490442,"about_ca_topic_score_gemma":0.001865252,"domain_scores_codex":[0.999804,0.00002016952,0.000009504718,0.00005278221,0.00009235524,0.00002123565],"domain_scores_gemma":[0.9996822,0.0001094436,0.00009190287,0.00003695552,0.00004385894,0.00003572275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001370123,0.00002544441,0.02029797,0.0002034935,0.00004725663,0.0001441299,0.00007011165,0.002228288,0.9649295,0.0005063016,0.0001895166,0.01122098],"study_design_scores_gemma":[0.00002375401,0.000274495,0.1311033,0.00002230508,0.00006903539,0.001478882,0.0002018642,0.03300406,0.8263875,0.001850392,0.005544926,0.00003943716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517911,0.0009123588,0.04407723,0.00009622979,0.000009287302,0.00002836702,0.0008052678,0.0003617995,0.001918331],"genre_scores_gemma":[0.9821274,0.0003103719,0.01588247,0.00005888929,0.000004247876,0.000023754,0.0008255061,0.00003141768,0.0007361004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869284,"threshold_uncertainty_score":0.006253421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00982566571794336,"score_gpt":0.1959330616304824,"score_spread":0.1861073959125391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}