{"id":"W2792255128","doi":"10.1016/j.biomaterials.2018.03.016","title":"Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation","year":2018,"lang":"en","type":"article","venue":"Biomaterials","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biofilm; Bacteria; Quartz crystal microbalance; Surface modification; Glycoside hydrolase; Adhesion; Microbiology; Biofouling; Pseudomonas aeruginosa; Glutaraldehyde; Materials science; Adsorption; Hydrolase; Biophysics; Covalent bond; Chemistry; Enzyme; Biochemistry; Chromatography; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003560732,0.0006314878,0.0003705395,0.0002401169,0.0002003526,0.0008014548,0.0003203456,0.0005279384,0.0008426142],"category_scores_gemma":[0.0005446214,0.0003033564,0.0002843609,0.0002150941,0.0004585506,0.0005792414,0.0002998901,0.0005987795,0.0002750766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000348839,"about_ca_system_score_gemma":0.0004349685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005987184,"about_ca_topic_score_gemma":0.001072063,"domain_scores_codex":[0.9996533,0.0000661333,0.0000249443,0.0000575751,0.00009109674,0.0001069479],"domain_scores_gemma":[0.9996594,0.0001589133,0.0000680371,0.0000344862,0.00003218372,0.00004701399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001748502,0.00003561722,0.000159445,0.00003690552,0.00000675799,0.00002841055,0.0000167512,0.00004350806,0.9981632,0.00005708624,0.00001860812,0.00125899],"study_design_scores_gemma":[0.000007408288,0.00009220278,0.0009131475,0.000003269312,0.000006411712,0.00003303453,0.0000135878,0.0002745232,0.9983371,0.00002334413,0.0002933129,0.00000248761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992731,0.002440916,0.003803453,0.00009243461,0.00003649107,0.00002304399,0.00007077968,0.00003339915,0.0007685373],"genre_scores_gemma":[0.9927796,0.0009843567,0.003849407,0.00008145884,0.0000193493,0.00001886241,0.0001407852,0.000035314,0.002090815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008426142,"threshold_uncertainty_score":0.002818763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099595858972413,"score_gpt":0.260863924623016,"score_spread":0.2498679660332919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}