{"id":"W2792255128","doi":"10.1016/j.biomaterials.2018.03.016","title":"Non-eluting, surface-bound enzymes disrupt surface attachment of bacteria by continuous biofilm polysaccharide degradation","year":2018,"lang":"en","type":"article","venue":"Biomaterials","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biofilm; Bacteria; Quartz crystal microbalance; Surface modification; Glycoside hydrolase; Adhesion; Microbiology; Biofouling; Pseudomonas aeruginosa; Glutaraldehyde; Materials science; Adsorption; Hydrolase; Biophysics; Covalent bond; Chemistry; Enzyme; Biochemistry; Chromatography; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003934883,0.0003102706,0.000420566,0.00003076275,0.0001443156,0.0001299279,0.0002237292,0.0002842735,0.0001897837],"category_scores_gemma":[0.0000419903,0.0002828494,0.00009404802,0.0001090843,0.0002512147,0.00001569866,0.0001724997,0.00001337336,0.00004055453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002280294,"about_ca_system_score_gemma":0.00007406386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000535808,"about_ca_topic_score_gemma":0.00002884583,"domain_scores_codex":[0.9981859,0.0001019939,0.0006005479,0.0005070259,0.0001599537,0.0004446245],"domain_scores_gemma":[0.9988022,0.0000113443,0.0004215234,0.0004671963,0.0001857451,0.0001120017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376852,0.0000743527,0.003927816,0.00003027075,0.00007992802,0.000001191926,0.00004480205,2.660151e-7,0.991128,0.00001251996,0.004241691,0.0002214226],"study_design_scores_gemma":[0.0005589466,0.0004795913,0.004223908,0.00004170064,0.00003539386,0.000008264091,0.00004721039,0.000005533279,0.9825795,0.000002574229,0.01168558,0.0003318385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971259,0.0002827889,0.00005620519,0.0001048326,0.001498715,0.0003157846,0.0004598624,0.00003449379,0.0001213792],"genre_scores_gemma":[0.9965271,0.00006898573,0.001593393,0.00008428371,0.0004877248,0.000002587229,0.0006356561,0.00004484786,0.0005554438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00854859,"threshold_uncertainty_score":0.9999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099595858972413,"score_gpt":0.260863924623016,"score_spread":0.2498679660332919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}