{"id":"W2792274945","doi":"10.1038/s41375-018-0012-5","title":"Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration","year":2018,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Leukemia and Lymphoma Society of Canada; Research Manitoba; Leukemia and Lymphoma Society","keywords":"Idelalisib; PI3K/AKT/mTOR pathway; Stromal cell; Chronic lymphocytic leukemia; Cancer research; Cell migration; Cell biology; Jurkat cells; Biology; Chemokine; T cell; Cell; Immunology; Leukemia; Signal transduction; Ibrutinib; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042629,0.0001412023,0.0002321721,0.00009799682,0.00007191716,0.0000302652,0.00007710006,0.0001009913,0.00005441291],"category_scores_gemma":[0.0001662204,0.0001184386,0.00004858575,0.0001586406,0.0001773499,0.00007275074,0.00004325905,0.0001023117,0.0000422621],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006113614,"about_ca_system_score_gemma":0.002364314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001946802,"about_ca_topic_score_gemma":0.003605314,"domain_scores_codex":[0.9988242,0.00002296255,0.000235789,0.0003326994,0.0002127874,0.0003716027],"domain_scores_gemma":[0.9992677,0.0001975644,0.00004829997,0.000258967,0.00009625945,0.0001312344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01641529,0.001092148,0.2853477,0.004937585,0.0002480342,0.00183096,0.008868902,0.00006332,0.4477877,0.003106743,0.1551686,0.07513295],"study_design_scores_gemma":[0.03601173,0.001540349,0.09519386,0.0006898482,0.0001172872,0.0002218903,0.0004736724,0.05371109,0.7764415,0.0008668074,0.0342314,0.0005005304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965527,0.0005873225,0.0002103498,0.0002757843,0.00006641843,0.0005704599,0.00001669543,0.00003960863,0.001680671],"genre_scores_gemma":[0.9965398,0.00007605297,0.001008306,0.000256433,0.0002983434,0.00008432617,0.00005246152,0.00002692058,0.001657327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3286538,"threshold_uncertainty_score":0.9977018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601825668664608,"score_gpt":0.2885638050431393,"score_spread":0.2725455483564932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}