{"id":"W2792317071","doi":"10.1038/s41419-018-0360-0","title":"Ceramide-induced BOK promotes mitochondrial fission in preeclampsia","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mitochondrial fission; MFN2; DNM1L; Mitochondrion; Mitophagy; Cell biology; FIS1; mitochondrial fusion; PINK1; Biology; MFN1; Autophagy; Programmed cell death; Apoptosis; Mitochondrial DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354497,0.0002088817,0.0003059209,0.0002895098,0.0001892204,0.0002672279,0.0001120301,0.0002402353,0.001005985],"category_scores_gemma":[0.000229961,0.0001493094,0.0002439196,0.0001625598,0.000225521,0.0002340108,0.0003672804,0.0006048359,0.0002643969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002731843,"about_ca_system_score_gemma":0.0001581884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003259264,"about_ca_topic_score_gemma":0.0002827872,"domain_scores_codex":[0.9998817,0.00001855605,0.00001728338,0.00001995838,0.00002878165,0.00003373697],"domain_scores_gemma":[0.9999118,0.00001083346,0.00002753197,0.000009753742,0.00000998416,0.00003002723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005503974,0.00002468522,0.0006473954,0.00005423504,0.000007088301,0.0004131861,0.0000431508,0.00002986667,0.9970522,0.00009158324,0.00003897428,0.001047092],"study_design_scores_gemma":[0.00006993437,0.0004537025,0.0317802,0.00001603757,0.00003510885,0.002949144,0.0001752995,0.001153287,0.9604678,0.0002981416,0.002591279,0.00001005618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957033,0.001655699,0.00135413,0.0001443492,0.00002541476,0.00002150892,0.000181502,0.00005112991,0.0008630921],"genre_scores_gemma":[0.997863,0.0007956505,0.0003485788,0.00004080087,0.000007062494,0.00001599249,0.0001816044,0.00000717981,0.0007403131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005985,"threshold_uncertainty_score":0.003365338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355765017148677,"score_gpt":0.2497306301085352,"score_spread":0.2361729799370484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}