{"id":"W2792317978","doi":"10.1093/jcag/gwy009.100","title":"A100 PANCREASTATIN WORSENS INTESTINAL INFLAMMATION BY INDUCING CLASSICALLY ACTIVATED MACROPHAGES (M1) THROUGH SUPPRESSION OF STAT3","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manitoba Beekeepers' Association; McGill University; University of Manitoba","funders":"","keywords":"STAT3; Colitis; Chromogranin A; Inflammatory bowel disease; Ulcerative colitis; Immunology; Internal medicine; Medicine; Biology; Immunohistochemistry; Phosphorylation; Disease; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008878512,0.0003386618,0.0003066764,0.0002397417,0.00007502838,0.00018299,0.0001085735,0.0002911609,0.001525799],"category_scores_gemma":[0.00008003753,0.0001199277,0.0002492929,0.0001261049,0.000192022,0.0001491583,0.0001576147,0.0008336595,0.0002141026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000986813,"about_ca_system_score_gemma":0.000135922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000261345,"about_ca_topic_score_gemma":0.0004380447,"domain_scores_codex":[0.9999194,0.00001207419,0.000009103842,0.00001426158,0.00002080953,0.00002432052],"domain_scores_gemma":[0.9999216,0.000006995634,0.00002477832,0.00000567247,0.000007445322,0.00003358551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111548,0.0001713307,0.0005868966,0.00007717365,0.00001377714,0.00004425801,0.000009690703,0.00003398085,0.9947225,0.00002077116,0.00008238033,0.003125662],"study_design_scores_gemma":[0.0005743146,0.01468349,0.06322249,0.00004764976,0.0001391384,0.001077882,0.000149493,0.001626749,0.9120162,0.0001841545,0.006264591,0.0000138956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956338,0.002553796,0.0005966633,0.0001297952,0.00004432345,0.00002104792,0.0002318923,0.00009133415,0.0006973898],"genre_scores_gemma":[0.9944081,0.001864734,0.0006966193,0.0001203339,0.00002047247,0.00004006965,0.0004397799,0.00001385564,0.002396139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525799,"threshold_uncertainty_score":0.005104303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007080144005463678,"score_gpt":0.2268830859428672,"score_spread":0.2198029419374035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}