{"id":"W2792335057","doi":"10.1128/mbio.01755-17","title":"Complement C5a Receptor 1 Exacerbates the Pathophysiology of<i>N. meningitidis</i>Sepsis and Is a Potential Target for Disease Treatment","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Deutsche Forschungsgemeinschaft; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Neisseria meningitidis; Immunology; Sepsis; C5a receptor; Meningococcal disease; Immune system; Complement system; Medicine; Innate immune system; In vivo; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002015198,0.0005620627,0.0003326769,0.0002347789,0.0001559404,0.0002981042,0.0002216585,0.0004670918,0.001278406],"category_scores_gemma":[0.0001000803,0.0001251218,0.0002880462,0.00007560338,0.00031189,0.000209069,0.0002167483,0.0008816226,0.0002693076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003233021,"about_ca_system_score_gemma":0.000268116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005929645,"about_ca_topic_score_gemma":0.000776596,"domain_scores_codex":[0.9998807,0.00002287098,0.000009787991,0.00001680483,0.00002581454,0.00004397941],"domain_scores_gemma":[0.9999019,0.000004815648,0.00004355705,0.000004703847,0.000009817244,0.00003532895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00121261,0.0001704168,0.001463671,0.0002211851,0.00002339535,0.0004262239,0.00002072278,0.0001070638,0.9901158,0.0003495003,0.0005903807,0.00529904],"study_design_scores_gemma":[0.0003823951,0.011424,0.1050749,0.0003134578,0.0002219078,0.005943613,0.0003793238,0.003245143,0.8532716,0.001046633,0.01864976,0.00004722533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825697,0.009060253,0.002856619,0.001220249,0.000197165,0.0001218016,0.0004077419,0.0002101017,0.003356397],"genre_scores_gemma":[0.9927998,0.003051055,0.001450182,0.0005495282,0.00008730198,0.0000478515,0.00031457,0.00001331827,0.001686349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001278406,"threshold_uncertainty_score":0.004276693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578266423106022,"score_gpt":0.2559578855408609,"score_spread":0.2401752213098007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}