{"id":"W2792339230","doi":"10.1016/j.bmcl.2018.01.053","title":"Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization","year":2018,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"ADME; Chemistry; In vivo; Pharmacology; Pharmacokinetics; Bioavailability; Microtubule polymerization; Microtubule; In vitro; Biochemistry; Tubulin; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003430769,0.0005131679,0.0004506715,0.0004507648,0.0003106964,0.0002918527,0.0005199678,0.0004803844,0.002385885],"category_scores_gemma":[0.0003717978,0.0003052465,0.0004467129,0.0002685338,0.0004366511,0.0004683687,0.00009664545,0.001483374,0.0003929527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177838,"about_ca_system_score_gemma":0.0004511964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315566,"about_ca_topic_score_gemma":0.002193297,"domain_scores_codex":[0.9998496,0.00004153858,0.000009306045,0.00002130277,0.00001977144,0.0000585518],"domain_scores_gemma":[0.9997461,0.00007063117,0.00004722501,0.00003321339,0.00001725184,0.00008547595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02073144,0.007117652,0.0006822833,0.0001689743,0.0001594861,0.0003288354,0.0001295886,0.002241435,0.9489131,0.0007035285,0.0009591617,0.01786451],"study_design_scores_gemma":[0.002102933,0.04870672,0.006245849,0.00002261915,0.0002156387,0.0003418815,0.00007462894,0.002589192,0.937083,0.0002395386,0.002349828,0.00002821743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955052,0.001158497,0.0005377175,0.0001486908,0.00007984147,0.00005823644,0.0003579223,0.00008261972,0.002071238],"genre_scores_gemma":[0.994752,0.001366763,0.0004487488,0.00005148077,0.00006494064,0.00006220488,0.0006539695,0.00002318533,0.002576546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002385885,"threshold_uncertainty_score":0.007981598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528710306998185,"score_gpt":0.2838546049290552,"score_spread":0.2685675018590733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}