{"id":"W2792387716","doi":"10.1083/jcb.201710095","title":"PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites","year":2018,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Akademie Věd České Republiky; Grantová Agentura České Republiky","keywords":"Phosphatidylinositol; Pi; Dephosphorylation; Pleckstrin homology domain; Endoplasmic reticulum; Phosphatidylserine; Cell biology; Membrane; Biology; Biochemistry; Biophysics; Phosphorylation; Phospholipid; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008648702,0.000310046,0.0002119205,0.0001494962,0.000210625,0.0005437972,0.0002635319,0.0002411514,0.001262702],"category_scores_gemma":[0.0001102025,0.0001371132,0.0002216105,0.0001384512,0.0001894275,0.0004720701,0.0004129093,0.000427734,0.0005130933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004446887,"about_ca_system_score_gemma":0.0001652358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006814344,"about_ca_topic_score_gemma":0.0008800153,"domain_scores_codex":[0.9998766,0.00001296743,0.00001204954,0.00003911817,0.00002958997,0.00002971592],"domain_scores_gemma":[0.9999477,0.000007658572,0.00001459027,0.000007800513,0.000008050016,0.0000142177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388952,0.0000126319,0.0003248971,0.00002908929,0.000002838347,0.00004608219,0.00001827532,0.00006827479,0.9967633,0.0002431634,0.00006048557,0.002291938],"study_design_scores_gemma":[0.00001482423,0.00007392689,0.008470908,0.000005111591,0.00001207761,0.00007247835,0.00007170422,0.001643351,0.986079,0.0001326171,0.003418453,0.000005499072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870582,0.001737903,0.00666033,0.0001489801,0.00004433542,0.00002981642,0.0003779809,0.000155732,0.003786641],"genre_scores_gemma":[0.9938893,0.0007922732,0.001858272,0.00005435063,0.000008009016,0.00002786446,0.0002968399,0.00002433086,0.003048626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262702,"threshold_uncertainty_score":0.004224122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919259568686024,"score_gpt":0.2662373040743684,"score_spread":0.2370447083875081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}