{"id":"W2792387716","doi":"10.1083/jcb.201710095","title":"PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER–PM contact sites","year":2018,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Akademie Věd České Republiky; Grantová Agentura České Republiky","keywords":"Phosphatidylinositol; Pi; Dephosphorylation; Pleckstrin homology domain; Endoplasmic reticulum; Phosphatidylserine; Cell biology; Membrane; Biology; Biochemistry; Biophysics; Phosphorylation; Phospholipid; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006419335,0.0001632473,0.0002784807,0.00005528306,0.00009762342,0.0000121949,0.0002252823,0.0001732363,0.0001546857],"category_scores_gemma":[0.00003379506,0.0001049376,0.00008755517,0.00005245842,0.000141683,0.00000569198,0.00004487264,0.000137258,0.00002176982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001383379,"about_ca_system_score_gemma":0.00005158301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001494618,"about_ca_topic_score_gemma":0.00008987018,"domain_scores_codex":[0.9989634,0.000172433,0.0003739616,0.0001616738,0.00008526978,0.0002432258],"domain_scores_gemma":[0.9991962,0.00005602805,0.0002288755,0.000207036,0.0001841533,0.0001276669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009803878,0.00003838784,0.0005257567,0.000007880005,0.00008570924,0.000004659817,0.0001915,0.000005508329,0.9966124,0.00003435882,0.0001228524,0.001390559],"study_design_scores_gemma":[0.001308351,0.002883819,0.001583191,0.00001155629,0.00008523429,0.0001155544,0.00005640051,0.00002849849,0.8879935,0.0001630855,0.1056337,0.0001371134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884483,0.001214238,0.008527609,0.000551732,0.0002633413,0.0002717736,0.00001765772,0.00000374595,0.0007016614],"genre_scores_gemma":[0.9973305,0.0006736282,0.0002987062,0.000721311,0.0005871078,0.000003706541,0.00007514366,0.00001416057,0.0002957194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1086189,"threshold_uncertainty_score":0.4279231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919259568686024,"score_gpt":0.2662373040743684,"score_spread":0.2370447083875081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}