{"id":"W2792399344","doi":"10.1158/1078-0432.ccr-17-2776","title":"Reactivation of cAMP Pathway by PDE4D Inhibition Represents a Novel Druggable Axis for Overcoming Tamoxifen Resistance in ER-positive Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"European Molecular Biology Organization","keywords":"Tamoxifen; Breast cancer; Pharmacology; Medicine; Cancer research; Drug resistance; Cancer; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001418649,0.0001093071,0.0002053592,0.0000768356,0.0001307925,0.00002023564,0.0001149685,0.0002327282,0.00005515829],"category_scores_gemma":[0.0004686377,0.0001029513,0.00008659239,0.0002913979,0.0003519632,0.00002188643,0.0001009762,0.0002104754,0.000002301326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001441115,"about_ca_system_score_gemma":0.0003135369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101307,"about_ca_topic_score_gemma":0.002554236,"domain_scores_codex":[0.9981771,0.0001881126,0.0004845821,0.0005287489,0.0003105229,0.0003109705],"domain_scores_gemma":[0.998427,0.0001855822,0.0001735216,0.0003007122,0.0008254307,0.00008771928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004811407,0.0003432713,0.01385686,0.00007011176,0.00005306711,6.990247e-7,0.0001828834,0.00001568247,0.9516031,0.0001048791,0.02401314,0.004944943],"study_design_scores_gemma":[0.003364392,0.0004442811,0.1023789,0.0004317175,0.00001029944,0.000001585586,0.0001169603,0.0002826969,0.8605766,0.0004134394,0.03175163,0.0002275502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947695,0.0004343196,0.001538013,0.001180723,0.0002675377,0.0006129203,0.0006219538,0.000006656791,0.0005684415],"genre_scores_gemma":[0.9957684,0.0003159643,0.0001855646,0.0001612059,0.0005875982,0.000292132,0.000211917,0.00002189065,0.002455336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09102651,"threshold_uncertainty_score":0.4198233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07550429526998252,"score_gpt":0.4344719173807309,"score_spread":0.3589676221107483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}