{"id":"W2792403302","doi":"10.1016/j.nbd.2018.02.016","title":"NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo","year":2018,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Science Foundation Ireland; Health Research Board","keywords":"Neuroinflammation; Long-term potentiation; Inflammasome; Synaptic plasticity; Neuroscience; Medicine; Receptor antagonist; Antagonist; Inflammation; Immunology; Biology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000390996,0.000908675,0.0006524745,0.0007241388,0.0006222483,0.0004549729,0.0005318105,0.001035082,0.001550014],"category_scores_gemma":[0.0001888958,0.0003465257,0.0006970187,0.0004061922,0.0007820663,0.0009980937,0.000407079,0.002388895,0.0004784555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004929025,"about_ca_system_score_gemma":0.0005097596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692993,"about_ca_topic_score_gemma":0.002211477,"domain_scores_codex":[0.9996219,0.00004131201,0.00005589579,0.00009242239,0.00008725976,0.0001012027],"domain_scores_gemma":[0.9996575,0.00002582698,0.000090584,0.00004623098,0.00005143979,0.0001283606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009758202,0.0002004392,0.0001525334,0.00004974801,0.00002518297,0.0003104682,0.00005819988,0.00007539795,0.9971771,0.00011635,0.00009097192,0.0007677248],"study_design_scores_gemma":[0.0001390001,0.001152787,0.006118069,0.00002141916,0.000110813,0.001241939,0.00021355,0.001956369,0.987754,0.0004512586,0.0008184672,0.00002233728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994586,0.0009017806,0.002213808,0.000220354,0.0001353234,0.00004390501,0.0006806899,0.0001069841,0.001111186],"genre_scores_gemma":[0.9927253,0.000763875,0.002096875,0.00008921452,0.000017752,0.0001112126,0.0004206311,0.000038165,0.003736969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692993,"threshold_uncertainty_score":0.005185306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0447614801228321,"score_gpt":0.2814072028059746,"score_spread":0.2366457226831425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}