{"id":"W2792447604","doi":"10.1002/chem.201800289","title":"Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461","year":2018,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Simon Fraser University","funders":"BC Cancer Agency; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Western Canada Research Grid; Compute Canada","keywords":"Bioavailability; Chemistry; Denticity; Cytotoxicity; Pyrazine; Solubility; Transition metal; Aqueous solution; Molecule; Drug; Metal ions in aqueous solution; Combinatorial chemistry; Coordination complex; Solubilization; Biophysics; Metal; Inorganic chemistry; Stereochemistry; Biochemistry; In vitro; Organic chemistry; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286312,0.0001925465,0.0002266912,0.00006614474,0.0001431577,0.0002374774,0.0001215811,0.0001413391,0.001678411],"category_scores_gemma":[0.0002488842,0.00009932316,0.00007275346,0.00004477803,0.0001338552,0.0001310488,0.0002253364,0.0002021815,0.00027204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064044,"about_ca_system_score_gemma":0.0001664973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007471489,"about_ca_topic_score_gemma":0.000682233,"domain_scores_codex":[0.9999249,0.00001605455,0.000005139756,0.00001504205,0.00001618518,0.00002264333],"domain_scores_gemma":[0.9999355,0.0000204253,0.00002017983,0.00000382562,0.000007336415,0.00001275122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002816939,0.00002988648,0.0001592964,0.00005142366,0.000008043399,0.0000414755,0.00002161358,0.0002888811,0.9959369,0.0001805694,0.0002289622,0.002771259],"study_design_scores_gemma":[0.00004716177,0.0003977738,0.0007125734,0.000005542838,0.00001223663,0.00004887264,0.00001314841,0.002370455,0.9949361,0.00005310623,0.001398999,0.000004046048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961539,0.001174055,0.0009708777,0.0001179458,0.00002017781,0.00001761394,0.00003511593,0.0000718871,0.001438453],"genre_scores_gemma":[0.9988546,0.0002431209,0.0003147169,0.0000191205,0.000004514992,0.000006517033,0.0000239037,0.000006419436,0.0005270301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001678411,"threshold_uncertainty_score":0.005614817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008870294681463197,"score_gpt":0.2231779667015052,"score_spread":0.214307672020042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}