{"id":"W2792513622","doi":"10.1016/j.ymthe.2018.03.011","title":"Tumor-Resident Dendritic Cells and Macrophages Modulate the Accumulation of TCR-Engineered T Cells in Melanoma","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Centers for Disease Control and Prevention; Medical Research Council; Bloodwise","keywords":"T-cell receptor; Tumor microenvironment; CD11c; Cancer research; T cell; Biology; Melanoma; Immunotherapy; Immunology; Antigen-presenting cell; Cancer immunotherapy; Chimeric antigen receptor; Cell biology; Immune system; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003816843,0.0001743319,0.000284622,0.0001830694,0.00004665975,0.00003089286,0.0001589658,0.00007218768,0.0006030031],"category_scores_gemma":[0.00001842063,0.0001295793,0.00008673075,0.0003010836,0.0001941661,0.00004265215,0.0000439006,0.0001909814,0.00002535036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005141275,"about_ca_system_score_gemma":0.00004729744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001931411,"about_ca_topic_score_gemma":0.00001853878,"domain_scores_codex":[0.9985703,0.0001631245,0.0002875394,0.0002758511,0.0003995869,0.0003036351],"domain_scores_gemma":[0.9991527,0.00008773932,0.00005982917,0.0004945792,0.0001201784,0.00008499018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003601977,0.00006748367,0.0005632552,0.00003253829,0.00007354141,0.0001289052,0.0006985022,0.0001335515,0.9905285,0.00005233057,0.0000455975,0.007315593],"study_design_scores_gemma":[0.002233502,0.0005569919,0.01836504,0.00005332362,0.00001672367,0.00002813069,0.00007059532,0.003339904,0.9740171,0.0002979303,0.0009035103,0.0001172558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962181,0.001728541,0.0005009707,0.000371795,0.0000995952,0.0007561714,0.000005822713,0.00002233132,0.0002966281],"genre_scores_gemma":[0.9980106,0.0004109215,0.0002531984,0.0003513283,0.00007993857,0.00002241343,0.000004999211,0.00004687613,0.0008197661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01780178,"threshold_uncertainty_score":0.6602461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02999586397732841,"score_gpt":0.3176004062087195,"score_spread":0.2876045422313911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}