{"id":"W2792514932","doi":"10.1074/mcp.ra118.000643","title":"Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS)","year":2018,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoproteomics; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; Biology; Kinome; Myristoylation; Autophosphorylation; Receptor tyrosine kinase; SH3 domain; Kinase; Cell biology; Chemistry; Phosphorylation; Signal transduction; Protein kinase A; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001911542,0.0005231071,0.0003190505,0.0003947118,0.0002745389,0.0004094111,0.0002316997,0.000302663,0.001696345],"category_scores_gemma":[0.0001965284,0.0001274732,0.0003731103,0.0002544956,0.0002100064,0.0003218272,0.0001981249,0.0004264076,0.0005566698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002241136,"about_ca_system_score_gemma":0.0002598634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004464636,"about_ca_topic_score_gemma":0.001220399,"domain_scores_codex":[0.999877,0.00001124264,0.000009456505,0.00004088053,0.00003609005,0.00002531394],"domain_scores_gemma":[0.9998996,0.00001586803,0.00003241545,0.00001040411,0.00001523812,0.00002636738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008663011,0.00001334827,0.0006101237,0.00003642798,0.00000989469,0.00008776996,0.000007121483,0.00003280146,0.9979913,0.00007339703,0.00002976246,0.001021558],"study_design_scores_gemma":[0.00001888551,0.0001857068,0.04230447,0.00000815046,0.00007567204,0.002070352,0.00006599729,0.001864908,0.9501708,0.0002378724,0.002984038,0.0000131125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891994,0.002184052,0.005708608,0.0001657128,0.00004066369,0.00002707081,0.001137265,0.00007145253,0.001465731],"genre_scores_gemma":[0.9847583,0.001591317,0.008368021,0.0001091043,0.00002260285,0.00002574752,0.002594474,0.00002477603,0.002505702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696345,"threshold_uncertainty_score":0.005674839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008072007124041932,"score_gpt":0.2271460743632868,"score_spread":0.2190740672392448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}