{"id":"W2792514932","doi":"10.1074/mcp.ra118.000643","title":"Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS)","year":2018,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoproteomics; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Biochemistry; Biology; Kinome; Myristoylation; Autophosphorylation; Receptor tyrosine kinase; SH3 domain; Kinase; Cell biology; Chemistry; Phosphorylation; Signal transduction; Protein kinase A; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006383635,0.0004591629,0.0004717397,0.0002299943,0.0003802442,0.0001345351,0.000399383,0.0003822718,0.00005979615],"category_scores_gemma":[0.0001344795,0.0004187504,0.0003694518,0.0007388671,0.0007295876,0.00003200511,0.000320129,0.0002395236,0.000005108299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006066506,"about_ca_system_score_gemma":0.0001550275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001217985,"about_ca_topic_score_gemma":0.0001060879,"domain_scores_codex":[0.9973914,0.0001716059,0.0007638183,0.0007854854,0.0004344712,0.0004532327],"domain_scores_gemma":[0.9978558,0.00001328321,0.0006504775,0.0009018262,0.000423115,0.0001554824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002026358,0.000104309,0.003785884,0.0000902586,0.0003245262,0.00002029435,0.0001369811,0.0005760331,0.9941577,0.0002291491,0.00002265274,0.0003496051],"study_design_scores_gemma":[0.001010212,0.0001809129,0.005915945,0.0001023682,0.0005276393,0.0000410704,0.00004683657,0.005802079,0.9855136,0.000189914,0.0001955772,0.0004738093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751109,0.002088399,0.0214489,0.00009664609,0.0001560744,0.0009305644,0.00008931469,0.00002933385,0.00004989752],"genre_scores_gemma":[0.9942039,0.00005456743,0.004607176,0.00009247296,0.0001567009,0.00004990908,0.0004860109,0.00006928723,0.0002799501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01909305,"threshold_uncertainty_score":0.9998264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008072007124041932,"score_gpt":0.2271460743632868,"score_spread":0.2190740672392448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}