{"id":"W2792521144","doi":"10.1055/a-0590-4992","title":"Genetics of Lithium Response in Bipolar Disorder","year":2018,"lang":"en","type":"review","venue":"Pharmacopsychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Lithium (medication); Bipolar disorder; Genetic architecture; Trait; Genetic association; Treatment of bipolar disorder; Genome-wide association study; Psychology; Medicine; Genetics; Biology; Psychiatry; Quantitative trait locus; Genotype; Single-nucleotide polymorphism; Gene; Computer science; Mania","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003352478,0.0004755211,0.0007599613,0.001512352,0.0001616477,0.0006407849,0.0004238347,0.0006308756,0.002412468],"category_scores_gemma":[0.0008509143,0.0001450409,0.0003884659,0.001296806,0.0003494756,0.000426545,0.0003078716,0.0006883299,0.0005548852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005000903,"about_ca_system_score_gemma":0.0009798304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002581825,"about_ca_topic_score_gemma":0.00278834,"domain_scores_codex":[0.9998699,0.00003309564,0.00002676248,0.00002423213,0.00003632821,0.000009581404],"domain_scores_gemma":[0.9997396,0.0001553885,0.00004468072,0.000005461961,0.000041752,0.00001317208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009853701,0.00003647939,0.001815583,0.0232505,0.0002137649,0.0005768307,0.000109865,0.0003624193,0.0005257245,0.003441382,0.02565808,0.9439108],"study_design_scores_gemma":[0.00005796061,0.0001528432,0.01284853,0.02651244,0.0009682589,0.01337633,0.0002205841,0.0002048931,0.0005059661,0.007971817,0.9371367,0.00004363542],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001621532,0.9987173,0.00004826524,0.0002842487,0.00007681215,0.000002977774,0.00001664157,0.000002795821,0.0006888047],"genre_scores_gemma":[0.001794888,0.9976198,0.00008512269,0.0001410332,0.0001205505,0.000003209698,0.00003384287,7.708051e-7,0.0002008267],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002581825,"threshold_uncertainty_score":0.008070529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389988076584681,"score_gpt":0.3838496126596849,"score_spread":0.3448508050012168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}