{"id":"W2792540082","doi":"10.1080/2162402x.2018.1442169","title":"Heating it up: Oncolytic viruses make tumors ‘hot’ and suitable for checkpoint blockade immunotherapies","year":2018,"lang":"en","type":"editorial","venue":"OncoImmunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Labex Immuno-Oncology; European Research Area Network on Cardiovascular Diseases; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Government of Canada; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Universitaire de France; Beatrice Hunter Cancer Research Institute; Fondation Leducq; European Commission","keywords":"Oncolytic virus; Blockade; Immune checkpoint; Tumor microenvironment; Medicine; Immunotherapy; Adjuvant; Cancer research; Immune system; Immunology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00120208,0.0006943492,0.0009299488,0.000222954,0.0004249888,0.0001276156,0.0008660064,0.00196605,0.0001689876],"category_scores_gemma":[0.001208939,0.0006995314,0.0002886,0.0001483927,0.0008033401,0.000008029928,0.0005163551,0.0008410799,0.00005716237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786309,"about_ca_system_score_gemma":0.001326074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003810952,"about_ca_topic_score_gemma":0.001275445,"domain_scores_codex":[0.9962379,0.0003069191,0.000750004,0.001181766,0.0004002784,0.001123145],"domain_scores_gemma":[0.9973124,0.0004642683,0.0004104133,0.001161132,0.0005412227,0.0001105501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006545833,0.0001030978,0.0000140961,0.0001578122,0.0007720802,0.000006031441,0.0002852001,0.000003605485,0.6294581,0.000005103461,0.3583909,0.004258175],"study_design_scores_gemma":[0.00241884,0.008359647,0.00001019929,0.0001230336,0.000059724,0.00001766125,0.0002347173,0.0000131873,0.2361815,0.0001085793,0.7519073,0.0005656429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.4752493,0.046703,0.0001811092,0.0006863302,0.4722756,0.002634109,0.000927781,0.0001484793,0.001194373],"genre_scores_gemma":[0.02463727,0.01395233,0.001904215,0.001284363,0.9023239,0.001985217,0.003372074,0.0009655516,0.04957508],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.450612,"threshold_uncertainty_score":0.9995456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087913009251936,"score_gpt":0.3290439763726339,"score_spread":0.3081648462801146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}