{"id":"W2792569575","doi":"10.1371/journal.pone.0190976","title":"Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Dry-powder inhaler; Inhalation; Chitosan; Inhaler; In vivo; Pharmacology; Particle size; Dosage form; Chemistry; Medicine; In vitro; Internal medicine; Anesthesia; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563572,0.0002240469,0.0001841164,0.0001840927,0.00008952067,0.0002317028,0.0001955322,0.0003352661,0.0004386981],"category_scores_gemma":[0.0001885501,0.0001279761,0.0002607793,0.00009554029,0.0001234923,0.000209979,0.0001270507,0.0003251741,0.0001353872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418488,"about_ca_system_score_gemma":0.000173412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000852676,"about_ca_topic_score_gemma":0.00151079,"domain_scores_codex":[0.9998932,0.00001076867,0.000007288935,0.00002243318,0.00005296149,0.00001344271],"domain_scores_gemma":[0.9999176,0.00001124522,0.00002773548,0.000004342006,0.00002480541,0.00001417838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005615745,0.00004887794,0.00007066113,0.0001065866,0.000005985947,0.00005321456,0.00001014214,0.0002144878,0.9946912,0.00005091128,0.00005954958,0.004632171],"study_design_scores_gemma":[0.00003074142,0.001628299,0.001700226,0.00001070324,0.00002958339,0.000173887,0.00001365424,0.001693583,0.991249,0.00001810491,0.00344128,0.00001110737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806389,0.006456631,0.008433013,0.000217363,0.00009663472,0.0002415146,0.0002161904,0.00009332973,0.003606364],"genre_scores_gemma":[0.9839407,0.003186255,0.009277222,0.00008549397,0.00002183926,0.0001084451,0.0001652418,0.00001606704,0.003198791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000852676,"threshold_uncertainty_score":0.001754701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09338190914997575,"score_gpt":0.296245834426831,"score_spread":0.2028639252768553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}