{"id":"W2792569575","doi":"10.1371/journal.pone.0190976","title":"Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Dry-powder inhaler; Inhalation; Chitosan; Inhaler; In vivo; Pharmacology; Particle size; Dosage form; Chemistry; Medicine; In vitro; Internal medicine; Anesthesia; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002787997,0.00005664278,0.0001349074,0.0001229093,0.00005667338,0.000002914965,0.00001744071,0.00004592371,0.00009185979],"category_scores_gemma":[0.0001295114,0.00004936006,0.00001663893,0.0001300812,0.00007355738,0.00006799689,0.00001056063,0.0000348903,0.000004534694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001701559,"about_ca_system_score_gemma":0.0002067998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002101267,"about_ca_topic_score_gemma":0.000006810472,"domain_scores_codex":[0.9989948,0.00004388097,0.0002889565,0.00009651281,0.0005067203,0.00006918001],"domain_scores_gemma":[0.9993351,0.00002564314,0.0001248387,0.000108739,0.0003661293,0.00003956279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006865725,0.0006161682,0.02803194,0.0001522386,0.00006494034,1.284687e-7,0.0007359518,0.00001294665,0.9654402,0.0001995894,0.000001917657,0.004675321],"study_design_scores_gemma":[0.001001971,0.00009340992,0.1499123,0.000218135,0.0001472391,2.410892e-7,0.00005193987,0.02222529,0.8262746,0.00002479362,0.000007625983,0.00004243498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972925,0.00004206393,0.00008556247,0.0001212274,0.000012609,0.0006111921,0.000001889266,0.00001611582,0.001816907],"genre_scores_gemma":[0.9869839,0.000001019543,0.01282384,0.00007792198,0.00004203386,0.00002873637,0.00001831213,0.000007309795,0.00001690677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1391656,"threshold_uncertainty_score":0.2012845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09338190914997575,"score_gpt":0.296245834426831,"score_spread":0.2028639252768553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}